Discovery of Clinically Used Octenidine as NRAS Repressor That Effectively Inhibits NRAS-Mutant Melanoma.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00094
Abstract: Mutations in NRAS promote tumorigenesis and drug resistance. As this protein is often considered an undruggable target, it is urgent to develop novel strategies to suppress NRAS for anticancer therapy. Recent reports indicated that a… read more here.
Keywords: discovery clinically; mutant melanoma; nras mutant; nras repressor ... See more keywords
T cell immunomodulation by clinically used allogeneic human cancellous bone fragments: a potential novel immunotherapy tool
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31979-1
Abstract: Multipotential stromal cells (MSCs) demonstrate strong immunomodulation capabilities following culture expansion. We have previously demonstrated that human cancellous bone fragments (CBFs) clinically used as viable allografts for spinal fusion have resident MSCs that exhibit T… read more here.
Keywords: clinically used; human cancellous; immunomodulation; cancellous bone ... See more keywords
Gold nanoparticles bearing a clinically used non-antibiotic drug for combating multi-drug resistant bacteria.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03460c
Abstract: We introduce N-acetyl-L-cysteine (NAC), a clinically used non-antibiotic drug, to the synthesis of antibacterial gold nanoparticles (Au_NAC). Au_NAC shows excellent antibacterial activities against multi-drug resistant (MDR) Gram-negative bacteria and possesses wound healing capabilities. We provide… read more here.
Keywords: gold nanoparticles; non antibiotic; used non; antibiotic drug ... See more keywords
Clinically used antifungal azoles as ligands for gold(III) complexes: the influence of the Au(III) ion on the antimicrobial activity of the complex.
Sign Up to like & getrecommendations! Published in 2022 at "Dalton transactions"
DOI: 10.1039/d2dt00411a
Abstract: In a search for novel antimicrobial metal-based therapeutic agents, mononuclear gold(III) complexes 1-7 of the general formula [AuCl3(azole)], where azole stands for imidazole (im, 1), 1-isopropylimidazole (ipim, 2), 1-phenylimidazole (phim, 3), clotrimazole (ctz, 4), econazole… read more here.
Keywords: iii complexes; iii; iii ion; clinically used ... See more keywords
Cell death and barrier disruption by clinically used iodine concentrations
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DOI: 10.26508/lsa.202201875
Abstract: Clinically used concentrations of povidone-iodine (PVP-I) are toxic to eukaryotic cells by attacking the lipid bilayer and tight junctions with fast kinetics and urge the reappraisal of PVP-I use. Povidone-iodine (PVP-I) inactivates a broad range… read more here.
Keywords: cell death; barrier; disruption; pvp ... See more keywords
Effect of Clinically Used Microtubule Targeting Drugs on Viral Infection and Transport Function
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DOI: 10.3390/ijms23073448
Abstract: Microtubule targeting agents (MTAs) have been exploited mainly as anti-cancer drugs because of their impact on cellular division and angiogenesis. Additionally, microtubules (MTs) are key structures for intracellular transport, which is frequently hijacked during viral… read more here.
Keywords: viral infection; microtubule targeting; effect; infection ... See more keywords
Copper(II) and Zinc(II) Complexes with the Clinically Used Fluconazole: Comparison of Antifungal Activity and Therapeutic Potential
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DOI: 10.3390/ph14010024
Abstract: Copper(II) and zinc(II) complexes with clinically used antifungal drug fluconazole (fcz), {[CuCl2(fcz)2].5H2O}n, 1, and {[ZnCl2(fcz)2]·2C2H5OH}n, 2, were prepared and characterized by spectroscopic and crystallographic methods. The polymeric structure of the complexes comprises four fluconazole molecules… read more here.
Keywords: clinically used; copper zinc; zinc complexes; antifungal activity ... See more keywords