Comparison of Publication of Pediatric Probiotic vs Antibiotic Trials Registered on ClinicalTrials.gov
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.25236
Abstract: Key Points Question Do registered trials that evaluate the use of probiotics and routinely used antibiotics in children differ in their publication rates? Findings This cross-sectional analysis of 265 unique probiotic trials and 136 unique… read more here.
Keywords: comparison publication; probiotic trials; clinicaltrials gov; publication ... See more keywords
Failure of Cardiovascular Phase 3 Randomized Clinical Trials to Report Pre-trial and Post-trial Parameters: a Cross-sectional Analysis of ClinicalTrials.gov
Sign Up to like & getrecommendations! Published in 2020 at "Journal of General Internal Medicine"
DOI: 10.1007/s11606-020-05995-9
Abstract: Randomized clinical trials (RCTs) are designed around a small number of pre-specified predicted values, including the trial’s hypothesized treatment effect, hypothesized control event rate, alpha, and power, knowing that these values are crucial to understanding… read more here.
Keywords: trial; clinicaltrials gov; randomized clinical; failure cardiovascular ... See more keywords
Prevalence of Control Groups in Cardiovascular Clinical Trials: An Analysis of ClinicalTrials.gov from 2009 through 2019.
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DOI: 10.1016/j.ahj.2020.12.006
Abstract: Clinical trials provide the foundational evidence that guide many patient-facing decisions however, the therapeutic effect and safety of an intervention is best evaluated when compared to a control group. We used ClinicalTrials.gov to describe the… read more here.
Keywords: cardiovascular clinical; control; clinicaltrials gov; prevalence ... See more keywords
Race and ethnicity reporting for clinical trials in ClinicalTrials.gov and publications.
Sign Up to like & getrecommendations! Published in 2020 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2020.106237
Abstract: Inclusion and subsequent reporting of minority participants in clinical trials are critical for ensuring external validity and detecting differences among subgroups, however reports suggest that ongoing gaps persist. ClinicalTrials.gov began requiring the reporting of race/ethnicity… read more here.
Keywords: ethnicity; clinicaltrials gov; race ethnicity; race ... See more keywords
Characteristics of studies of pharmacist services registered in ClinicalTrials.gov.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Pharmacists Association : JAPhA"
DOI: 10.1016/j.japh.2019.12.001
Abstract: OBJECTIVE To examine the characteristics of studies of pharmacist services registered in ClinicalTrials.gov. DESIGN Cross-sectional study. SETTING AND PARTICIPANTS ClinicalTrials.gov and MEDLINE databases were searched to identify studies of pharmacist services. Registration information was obtained… read more here.
Keywords: services registered; registered clinicaltrials; studies pharmacist; clinicaltrials gov ... See more keywords
Extending PubMed searches to ClinicalTrials.gov through a machine learning approach for systematic reviews.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2018.06.015
Abstract: OBJECTIVES Despite their essential role in collecting and organizing published medical literature, indexed search engines are unable to cover all relevant knowledge. Hence, current literature recommends the inclusion of clinical trial registries in systematic reviews… read more here.
Keywords: machine; machine learning; extending pubmed; clinicaltrials gov ... See more keywords
A very brief self-report scale for measuring insomnia severity using two items from the Insomnia Severity Index - development and validation in a clinical population.
Sign Up to like & getrecommendations! Published in 2021 at "Sleep medicine"
DOI: 10.1016/j.sleep.2021.03.003
Abstract: OBJECTIVE To develop a very brief scale with selected items from the Insomnia Severity Index (ISI), and to investigate the psychometric properties of the proposed scale in a psychiatric sample. METHODS Patient data from seven… read more here.
Keywords: insomnia severity; clinicaltrials gov; https; items insomnia ... See more keywords
Compliance on Mandatory Data Reporting in Registered Obstetrics Trials
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Perinatology"
DOI: 10.1055/s-0038-1642620
Abstract: Background The Food and Drug Administration's (FDA's) Amendments Act established a legal mandate requiring registration of certain drug, device, and biologics trials in ClinicalTrials.gov prior to patient enrollment. One provision of the act requires investigators… read more here.
Keywords: reporting; clinicaltrials gov; compliance; compliance mandatory ... See more keywords
Ridinilazole for the treatment of Clostridioides difficile infection
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2019.1582640
Abstract: ABSTRACT Introduction: Ridinilazole is a novel antibiotic being developed for the treatment of Clostridioides difficile infection (CDI). Ridinilazole has completed two phase II trials and phase III trials which are denoted Ri-CoDIFy 1 and 2,… read more here.
Keywords: trial; cdi; treatment clostridioides; clinicaltrials gov ... See more keywords
The NK1 receptor antagonist serlopitant for treatment of chronic pruritus
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2019.1638910
Abstract: ABSTRACT Introduction: Pruritus is a common symptom associated with several potential underlying causes, including both dermatologic and systemic diseases; it can also occur without an identifiable cause. Current treatment options are limited and most patients… read more here.
Keywords: trial registration; clinicaltrials gov; gov identifier; registration clinicaltrials ... See more keywords
Investigational drugs in early-stage clinical trials for autism spectrum disorder
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2019.1649656
Abstract: ABSTRACT Introduction: Pharmacologic interventions in Autism Spectrum Disorder (ASD) have historically focused on symptom-based approaches. However, a treatment for the core social deficits has remained unidentified. While a definitive theory for the cause of ASD… read more here.
Keywords: trial registration; clinicaltrials gov; gov identifier; registration clinicaltrials ... See more keywords