An overview of cdc2‐like kinase 1 (Clk1) inhibitors and their therapeutic indications
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DOI: 10.1002/med.21928
Abstract: Over the past decade, Clk1 has been identified as a promising target for the treatment of various diseases, in which deregulated alternative splicing plays a role. First small molecules targeting Clk1 are in clinical trials… read more here.
Keywords: like kinase; overview cdc2; clk1; alternative splicing ... See more keywords
Structure-guided screening identified bioactive phytoconstituents Hernandonine and Anolobine as potential inhibitors of dual specificity protein kinase CLK1
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DOI: 10.1038/s41598-025-97753-2
Abstract: Neurodegenerative diseases such as Alzheimer’s disease (AD) are becoming a global health concern because of their progressive nature and the extent of the disability they cause to the affected individuals. Existing therapies for neurodegenerative diseases… read more here.
Keywords: dual specificity; protein kinase; hernandonine anolobine; clk1 ... See more keywords
Induction of beige‐like adipocyte markers and functions in 3T3‐L1 cells by Clk1 and PKCβII inhibitory molecules
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DOI: 10.1111/jcmm.17345
Abstract: Excessive dietary intake of fat results in its storage in white adipose tissue (WAT). Energy expenditure through lipid oxidation occurs in brown adipose tissue (BAT). Certain WAT depots can undergo a change termed beiging where… read more here.
Keywords: inhibition; pgc1; clk1; clk1 pkc ... See more keywords
CLK1 Activates YAP to Promote Intrahepatic Cholangiocarcinogenesis.
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DOI: 10.1158/0008-5472.can-24-0147
Abstract: Cdc2-like kinase 1 (CLK1) has dual-specificity kinase ability to phosphorylate tyrosine and serine/threonine protein residues. CLK1 regulates many physiological processes and has been shown to contribute to multiple types of cancer. Here, we investigated the… read more here.
Keywords: akt clk1; clk1; icc; activates yap ... See more keywords
Stable H-bond networks are crucial for selective CLK1 inhibition: a computational perspective
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DOI: 10.3389/fchem.2025.1582515
Abstract: Studying the selectivity mechanism of inhibitors towards highly similar isoforms is an important task in the development of new drugs, which are designed to avoid the undesired side effects in vivo. CDC-like kinase isoforms (CLKs)… read more here.
Keywords: selective clk1; clk1 inhibition; computational perspective; clk1 ... See more keywords
N-Benzylated 5-Hydroxybenzothiophene-2-carboxamides as Multi-Targeted Clk/Dyrk Inhibitors and Potential Anticancer Agents
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DOI: 10.3390/cancers16112033
Abstract: Simple Summary The demand for multitarget-directed anticancer agents has been steadily increasing, as cancer remains a leading cause of death worldwide. Dyrk and Clk kinases play crucial roles in cancer cell division and survival. Our… read more here.
Keywords: cancer; dyrk1b clk1; anticancer agents; dyrk1a dyrk1b ... See more keywords