An overview of cdc2‐like kinase 1 (Clk1) inhibitors and their therapeutic indications
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DOI: 10.1002/med.21928
Abstract: Over the past decade, Clk1 has been identified as a promising target for the treatment of various diseases, in which deregulated alternative splicing plays a role. First small molecules targeting Clk1 are in clinical trials… read more here.
Keywords: like kinase; overview cdc2; clk1; alternative splicing ... See more keywords
Straightforward Access to a New Class of Dual DYRK1A/CLK1 Inhibitors Possessing a Simple Dihydroquinoline Core
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DOI: 10.3390/molecules28010036
Abstract: The DYRK (Dual-specificity tyrosine phosphorylation-regulated kinase) family of protein kinases is involved in the pathogenesis of several neurodegenerative diseases. Among them, the DYRK1A protein kinase is thought to be implicated in Alzheimer’s disease (AD) and… read more here.
Keywords: new class; dyrk1a clk1; class; clk1 inhibitors ... See more keywords