X‐ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan–McDermid Syndrome
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DOI: 10.1002/cmdc.201800344
Abstract: CLK2 inhibition has been proposed as a potential mechanism to improve autism and neuronal functions in Phelan–McDermid syndrome (PMDS). Herein, the discovery of a very potent indazole CLK inhibitor series and the CLK2 X‐ray structure… read more here.
Keywords: clk2 inhibitors; clk2; ray structures; ray ... See more keywords
Structural Basis for the Selective Inhibition of Cdc2-Like Kinases by CX-4945
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DOI: 10.1155/2019/6125068
Abstract: Cdc2-like kinases (CLKs) play a crucial role in the alternative splicing of eukaryotic pre-mRNAs through the phosphorylation of serine/arginine-rich proteins (SR proteins). Dysregulation of this processes is linked with various diseases including cancers, neurodegenerative diseases,… read more here.
Keywords: structural basis; cdc2 like; clk2; basis selective ... See more keywords
CLK2 Expression Is Associated with the Progression of Colorectal Cancer and Is a Prognostic Biomarker
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DOI: 10.1155/2022/7250127
Abstract: Background CLK2 is a splicing regulator and expressed ubiquitously in various malignancies. The study is aimed at exploring the potential roles of CLK2 in the development of colorectal cancer (CRC). Methods Real-time PCR and analyses… read more here.
Keywords: expression; prognostic biomarker; colorectal cancer; clk2 ... See more keywords
CDC Like Kinase 2 plays an oncogenic role in colorectal cancer via modulating the Wnt/β-catenin signaling.
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DOI: 10.4149/neo_2022_220206n138
Abstract: Colorectal cancer (CRC) is a common malignant tumor with high morbidity and mortality, and significant heterogeneity among patients. In this study, we aimed to explore the role and mechanism of CLK2 in CRC, a kinase… read more here.
Keywords: role; wnt catenin; crc; colorectal cancer ... See more keywords