X‐ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan–McDermid Syndrome
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DOI: 10.1002/cmdc.201800344
Abstract: CLK2 inhibition has been proposed as a potential mechanism to improve autism and neuronal functions in Phelan–McDermid syndrome (PMDS). Herein, the discovery of a very potent indazole CLK inhibitor series and the CLK2 X‐ray structure… read more here.
Keywords: clk2 inhibitors; clk2; ray structures; ray ... See more keywords