Lenalidomide abrogates the survival effect of bone marrow stromal cells in chronic lymphocytic leukemia
Sign Up to like & getrecommendations! Published in 2021 at "Hematological Oncology"
DOI: 10.1002/hon.2888
Abstract: In the pathogenesis of chronic lymphocytic leukemia (CLL) the microenvironment plays an important role, as it produces survival signals and mediates drug resistance. Lenalidomide, which has immunomodulatory effect, can enhance the activation of T‐, NK‐cells… read more here.
Keywords: cll; cll cells; lymphocytic leukemia; effect ... See more keywords
Chronic lymphocytic leukemia cells increase neutrophils survival and promote their differentiation into CD16highCD62Ldim immunosuppressive subset
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.31762
Abstract: Reprogramming of neutrophils by malignant cells is well‐described for many types of solid tumors, but data remain scarce for hematological diseases. Chronic lymphocytic leukemia (CLL) is characterized for a deep immune dysregulation mediated by leukemic… read more here.
Keywords: cll; cll cells; lymphocytic leukemia; cd16highcd62ldim ... See more keywords
Venetoclax-resistant CLL cells show a highly activated and proliferative phenotype
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-021-03043-x
Abstract: Venetoclax treatment has demonstrated efficacy and a safety profile in chronic lymphocytic leukemia (CLL) patients, however the emergence of resistant cells is a current complication. We and others, previously reported that the activation of CLL… read more here.
Keywords: phenotype; resistant cll; cll; venetoclax ... See more keywords
BAFF signaling in health and disease.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2021.06.014
Abstract: BAFF is a critical cytokine supporting the survival of mature naïve B cells, acting through the BAFFR receptor. Recent studies show that BAFF and BAFFR are also required for the survival of memory B cells,… read more here.
Keywords: signaling health; baff signaling; baffr; health disease ... See more keywords
A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eμ-TCL1 mice through the JNK/STAT4/p66Shc axis.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105965
Abstract: Survival and expansion of malignant B cells in chronic lymphocytic leukemia (CLL) are highly dependent both on intrinsic defects in the apoptotic machinery and on the interactions with cells and soluble factors in the lymphoid… read more here.
Keywords: p66shc expression; cll; cll cells; oxazepine based ... See more keywords
SIRT3 overexpression and epigenetic silencing of catalase regulate ROS accumulation in CLL cells activating AXL signaling axis
Sign Up to like & getrecommendations! Published in 2021 at "Blood Cancer Journal"
DOI: 10.1038/s41408-021-00484-6
Abstract: Mitochondrial metabolism is the key source for abundant ROS in chronic lymphocytic leukemia (CLL) cells. Here, we detected significantly lower superoxide anion (O2−) levels with increased accumulation of hydrogen peroxide (H2O2) in CLL cells vs.… read more here.
Keywords: cll; ros accumulation; accumulation cll; sirt3 overexpression ... See more keywords
HLA ligandome analysis of primary chronic lymphocytic leukemia (CLL) cells under lenalidomide treatment confirms the suitability of lenalidomide for combination with T-cell-based immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "OncoImmunology"
DOI: 10.1080/2162402x.2017.1316438
Abstract: ABSTRACT Recent studies suggest that CLL is an immunogenic disease, which might be effectively targeted by antigen-specific T-cell-based immunotherapy. However, CLL is associated with a profound immune defect, which might represent a critical limitation for… read more here.
Keywords: cll; cell based; lenalidomide treatment; based immunotherapy ... See more keywords
Combination targeted therapy in chronic lymphocytic leukaemia – can pre‐clinical studies translate to the clinic?
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Haematology"
DOI: 10.1111/bjh.15279
Abstract: Identifying effective or synergistic combinations of targeted therapies and studying the tumour microenvironment (TME) are priority areas for lymphoma discovery and translation. This is particularly true for lymphoma patients who have more aggressive disease or… read more here.
Keywords: cll; tumour cells; chronic lymphocytic; tme ... See more keywords
Abnormal eosinophil count at CLL diagnosis correlates with shorter treatment free survival
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Haematology"
DOI: 10.1111/bjh.17264
Abstract: pression of CD5 and CD19. (D) CLL cells showed bimodal expression of CD49d. Three fractions were sorted for downstream analysis. Purity checks of these fractions are shown: CD49d CLL cells (E), CD49d CLL cells (F)… read more here.
Keywords: cll; abnormal eosinophil; cd49d cll; cll cells ... See more keywords
SPOT-008 Neurotensin receptor type 2 protects B-cell chronic lymphocytic leukaemia cells from apoptosis
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DOI: 10.1136/esmoopen-2018-eacr25.41
Abstract: Introduction B-cell chronic lymphocytic leukaemia (B-CLL) cells are resistant to apoptosis, and consequently accumulate to the detriment of normal B cells and patient immunity. Because current therapies fail to eradicate these apoptosis-resistant cells, it is… read more here.
Keywords: cll; cll cells; interaction; receptor ... See more keywords
MALT1 Inhibition Is Efficacious in Both Naïve and Ibrutinib-Resistant Chronic Lymphocytic Leukemia.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-2485
Abstract: The clinical efficacy displayed by ibrutinib in chronic lymphocytic leukemia (CLL) has been challenged by the frequent emergence of resistant clones. The ibrutinib target, Bruton's tyrosine kinase (BTK), is essential for B-cell receptor signaling, and… read more here.
Keywords: cll; ibrutinib; lymphocytic leukemia; cll cells ... See more keywords