A PHASE I/II TRIAL OF IBRUTINIB, INTRATUMORAL CPG AND LOCAL RADIATION IN PATIENTS WITH LOW‐GRADE B‐CELL LYMPHOMA: INTERIM CLINICAL AND CORRELATIVE RESULTS
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DOI: 10.1002/hon.82_2629
Abstract: lets >40,000/μL, adequate renal and hepatic function and no significant cardiac disease. Growth factors, transfusion and anticoagulation were allowed. The primary efficacy endpoint was objective response using 2007 International Working Group criteria. Results: As of… read more here.
Keywords: cll; cell; response; cll sll ... See more keywords
Sequential development of monoclonal B cell lymphocytosis-derived small lymphocytic lymphoma and plasma cell leukemia
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DOI: 10.1007/s00277-018-3248-2
Abstract: Dear Editor, Accumulating evidence suggests that monoclonal B cell lymphocytosis (MBL) is a precursor condition for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/ SLL). Other MBL-derived B cell malignancies are quite rare, and the clonal evolution… read more here.
Keywords: cell; mbl; plasma cell; cll sll ... See more keywords
Leukemia cutis in accelerated chronic lymphocytic leukemia: successful treatment with venetoclax and rituximab
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DOI: 10.1007/s00277-022-04753-7
Abstract: Dear Editor, Chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) is an indolent form of small mature B-cell leukemia that predominantly affects older individuals [1]. In the World Health Organization (WHO) classification, CLL and SLL are… read more here.
Keywords: cll; treatment; leukemia; cll sll ... See more keywords
Building a new score system for the diagnosis and differential diagnosis of typical CLL/SLL, atypical CLL/SLL, and MCL based on the flow cytometry immunophenotyping
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DOI: 10.1007/s00277-025-06231-2
Abstract: The diagnosis and differential diagnosis of typical lymphocytic leukaemia (CLL)/Small lymphocytic lymphoma(SLL) especially atypical CLL/SLL (aCLL/SLL), and mantle cell lymphoma (MCL) remains highly challenging. Thus, we evaluated the accuracy of the combination of the Moreau… read more here.
Keywords: diagnosis; mcl; atypical cll; cll ... See more keywords
Infectious complications in CLL/SLL patients receiving Bruton's Tyrosine Kinase inhibitors – systematic review and meta-analysis of randomized controlled trials
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DOI: 10.1007/s00277-025-06502-y
Abstract: The development of Bruton Tyrosine Kinase inhibitors (BTKis) has revolutionized the management of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). However, increased infection rates have been reported in patients receiving BTKis in multiple clinical trials. This… read more here.
Keywords: anti cd20; risk; tyrosine kinase; sll patients ... See more keywords
Clinical utility of chromosomal microarray in establishing clonality and high risk features in patients with Richter transformation.
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DOI: 10.1016/j.cancergen.2021.10.003
Abstract: Richter transformation (RT) refers to the development of an aggressive lymphoma in patients with pre-existing chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). It carries a poor prognosis secondary to poor response to therapy or rapid disease… read more here.
Keywords: patients richter; chromosomal microarray; transformation; richter transformation ... See more keywords
Abstract CT158: Unmutated IGHV is not an adverse predictor of outcome to therapy with ibrutinib in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)
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DOI: 10.1158/1538-7445.am2017-ct158
Abstract: Background: Patients (pts) with CLL/SLL who use unmutated IGHV (u-CLL) have a less favorable outcome with standard chemotherapy than pts who use mutated IGHV (m-CLL). Ibrutinib (ibr) inhibits B-cell receptor signaling through Bruton’s tyrosine kinase… read more here.
Keywords: cll; ibr; comp; unmutated ighv ... See more keywords
Long Term Outcomes of Venetoclax Therapy for Complex Karyotype Relapsed/Refractory Chronic Lymphocytic Leukemia
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DOI: 10.1182/blood-2018-99-113905
Abstract: Background The selective BCL2 inhibitor venetoclax (Ven) achieves an overall response rate of approximately 75 - 80% as a single agent in patients (pts) with relapsed and refractory chronic lymphocytic leukemia / small lymphocytic lymphoma… read more here.
Keywords: research; funding; pts cll; research funding ... See more keywords
A Phase I Study of Duvelisib and Venetoclax in Patients with Relapsed or Refractory CLL / SLL
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DOI: 10.1182/blood-2019-127343
Abstract: Introduction: Duvelisib (DUV), an oral inhibitor of PI3K-δ/γ, and venetoclax (VEN), an oral inhibitor of BCL-2, are both approved for relapsed/refractory (R/R) CLL. We previously found that PI3K-δ inhibition sensitizes CLL cells to ex vivo… read more here.
Keywords: gr3; cll sll; consultancy; research funding ... See more keywords
A Phase 1 a/b Dose Escalation Trial to Evaluate the Safety and Tolerability of CG-806 in Patients with Relapsed or Refractory CLL/SLL or Non-Hodgkin's Lymphomas
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DOI: 10.1182/blood-2019-130784
Abstract: INTRODUCTION: CG-806 is a first-in-class, oral, non-covalent, and potent inhibitor of the wild type and all known mutant forms of Bruton's tyrosine kinase (BTK, including the C481S mutation), as well as all forms of the… read more here.
Keywords: trial; safety; tolerability; sll non ... See more keywords
Real-World Bleeding Risk, Outcomes and Treatment Patterns of Patients with CLL/SLL Receiving BTKi with or without Prescription Anticoagulants or Antiplatelets
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DOI: 10.1182/blood-2024-198724
Abstract: Introduction: Bruton tyrosine kinase inhibitors (BTKi) have transformed the treatment (tx) landscape of CLL/SLL. However, BTKi are associated with an increased risk of bleeding events that may complicate their use in patients (pts) with thrombotic… read more here.
Keywords: first bleed; real world; cll sll; btki ... See more keywords