Biochemical mechanism of the mammalian circadian clock.
Sign Up to like & getrecommendations! Published in 2025 at "FEBS letters"
DOI: 10.1002/1873-3468.70150
Abstract: Circadian rhythms, regulated by core clock proteins, coordinate physiological functions with daily environmental fluctuations across organisms, from bacteria to humans. The circadian clock interacts with various biological processes, and its disruption is associated with numerous… read more here.
Keywords: mechanism mammalian; clock; biochemical mechanism; mammalian circadian ... See more keywords
Phosphorylation of CLOCK and BMAL1-a key regulatory mechanism in the mammalian circadian clockwork.
Sign Up to like & getrecommendations! Published in 2025 at "FEBS letters"
DOI: 10.1002/1873-3468.70194
Abstract: In the mammalian circadian clockwork, transcriptional-translational feedback loops are mediated by the core clock proteins, CLOCK and BMAL1. Although the transcriptional activation function of the CLOCK-BMAL1 complex has been well-characterized, the mechanisms underpinning its inactivation,… read more here.
Keywords: mammalian circadian; clock bmal1; circadian clockwork; clock ... See more keywords
Circadian clock regulation via biomaterials for nucleus pulposus.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202301037
Abstract: Circadian clock disorder during tissue degeneration has been considered the potential pathogenesis for various chronic diseases, such as intervertebral disc degeneration (IVDD). In this study, circadian clock-regulating biomaterials (ClockMPs) that could effectively activate the intrinsic… read more here.
Keywords: circadian clock; clockmps could; clock regulation; nucleus pulposus ... See more keywords
The PRMT6/PARP1/CRL4B Complex Regulates the Circadian Clock and Promotes Breast Tumorigenesis
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DOI: 10.1002/advs.202202737
Abstract: Circadian rhythms, as physiological systems with self‐regulatory functions in living organisms, are controlled by core clock genes and are involved in tumor development. The protein arginine methyltransferase 6 (PRMT6) serves as an oncogene in a… read more here.
Keywords: prmt6; crl4b complex; promotes breast; breast cancer ... See more keywords
No phylogenomic support for a Cenozoic origin of the “living fossil” Isoetes
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Botany"
DOI: 10.1002/ajb2.16108
Abstract: Abstract Premise The isoetalean lineage has a rich fossil record that extends to the Devonian, but the age of the living clade is unclear. Recent results indicate that it is young, from the Cenozoic, whereas… read more here.
Keywords: cenozoic; cenozoic origin; clock model; support cenozoic ... See more keywords
Multipartite Quantum Clock Synchronization under The Influence of Unruh Thermal Noise
Sign Up to like & getrecommendations! Published in 2019 at "Annalen der Physik"
DOI: 10.1002/andp.201900067
Abstract: A protocol for multipartite quantum clock synchronization is performed under the influence of Unruh thermal noise. The dynamics of multipartite quantum system consisting of Unruh–DeWitt detectors when one of the detectors is accelerated are obtained.… read more here.
Keywords: thermal noise; multipartite; clock synchronization; multipartite quantum ... See more keywords
Data partitioning and correction for ascertainment bias reduce the uncertainty of placental mammal divergence times inferred from the morphological clock
Sign Up to like & getrecommendations! Published in 2019 at "Ecology and Evolution"
DOI: 10.1002/ece3.4921
Abstract: Abstract Bayesian estimates of divergence times based on the molecular clock yield uncertainty of parameter estimates measured by the width of posterior distributions of node ages. For the relaxed molecular clock, previous works have reported… read more here.
Keywords: clock; morphological clock; uncertainty; times inferred ... See more keywords
The intrinsic microglial clock system regulates interleukin‐6 expression
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DOI: 10.1002/glia.23087
Abstract: Similar to neurons, microglia have an intrinsic molecular clock. The master clock oscillator Bmal1 modulates interleukin‐6 upregulation in microglial cells exposed to lipopolysaccharide. Bmal1 can play a role in microglial inflammatory responses. We previously demonstrated… read more here.
Keywords: interleukin expression; intrinsic microglial; expression; mice ... See more keywords
The Clock‐NAD+‐Sirtuin connection in nonalcoholic fatty liver disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30772
Abstract: Nonalcoholic or metabolic associated fatty liver disease (NAFLD/MAFLD) is a hepatic reflection of metabolic derangements characterized by excess fat deposition in the hepatocytes. Identifying metabolic regulatory nodes in fatty liver pathology is essential for effective… read more here.
Keywords: clock nad; fatty liver; connection; liver disease ... See more keywords
Expression of circadian clock genes in leukocytes of patients with Meniere's disease
Sign Up to like & getrecommendations! Published in 2022 at "Laryngoscope Investigative Otolaryngology"
DOI: 10.1002/lio2.757
Abstract: The underlying etiology of Meniere's disease (MD) is not completely clear, but the precipitated triggers may alter the circadian clock in patients with MD. This study aims to survey the expression of circadian clock genes… read more here.
Keywords: circadian clock; expression circadian; leukocytes patients; meniere disease ... See more keywords
Association of Genes Involved in the Circadian Clock With Polysomes in the Bovine Preimplantation Embryo
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DOI: 10.1002/mrd.70054
Abstract: The circadian clock is not functional during preimplantation development because lack of transcription prevents the feedback loop required for circadian cyclicity. Moreover, transcript abundance for the core clock genes (CLOCK, ARNTL, PER1, PER2, CRY1, and… read more here.
Keywords: cell stage; stage; clock; preimplantation embryo ... See more keywords