Biochemical mechanism of the mammalian circadian clock.
Sign Up to like & getrecommendations! Published in 2025 at "FEBS letters"
DOI: 10.1002/1873-3468.70150
Abstract: Circadian rhythms, regulated by core clock proteins, coordinate physiological functions with daily environmental fluctuations across organisms, from bacteria to humans. The circadian clock interacts with various biological processes, and its disruption is associated with numerous… read more here.
Keywords: mechanism mammalian; clock; biochemical mechanism; mammalian circadian ... See more keywords
Phosphorylation of CLOCK and BMAL1-a key regulatory mechanism in the mammalian circadian clockwork.
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DOI: 10.1002/1873-3468.70194
Abstract: In the mammalian circadian clockwork, transcriptional-translational feedback loops are mediated by the core clock proteins, CLOCK and BMAL1. Although the transcriptional activation function of the CLOCK-BMAL1 complex has been well-characterized, the mechanisms underpinning its inactivation,… read more here.
Keywords: mammalian circadian; clock bmal1; circadian clockwork; clock ... See more keywords
NSP-C contributes to the upregulation of CLOCK/BMAL1-mediated transcription
Sign Up to like & getrecommendations! Published in 2018 at "Cytotechnology"
DOI: 10.1007/s10616-018-0266-9
Abstract: The bHLH-PAS transcription factors clock circadian regulator (CLOCK) and brain and muscle ARNT-like protein 1 (BMAL1) play essential roles in the generation of circadian gene expression rhythms through the activation of E-box-mediated transcription. Importantly, circadian… read more here.
Keywords: bmal1; clock bmal1; bmal1 mediated; clock ... See more keywords
Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2114083119
Abstract: Significance Although the circadian clock is essential for regulating the temporal order of physiological functions, circadian oscillation is strictly suppressed in the early-to-mid–stage embryos in mammalian developmental process. The biological significance controlling the suppression of… read more here.
Keywords: clock bmal1; segmentation clock; clock; circadian key ... See more keywords
Phosphorylation of DNA-binding domains of CLOCK–BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2316858121
Abstract: Significance It has long been established that circadian clock oscillations rely on transcriptional and translational feedback loops but the specific phosphorylation sites underlying the displacement of the CLOCK–BMAL1 complex are still elusive. In this study,… read more here.
Keywords: phosphorylation; clock; clock bmal1; per dependent ... See more keywords
Regulatory Effects of Clock and Bmal1 on Circadian Rhythmic TLR Expression.
Sign Up to like & getrecommendations! Published in 2021 at "International reviews of immunology"
DOI: 10.1080/08830185.2021.1931170
Abstract: Circadian locomotor output cycles kaput (Clock) and brain and muscle ARNT-like 1 (Bmal1) are two core circadian clock genes. They form a heterodimer that can bind to the E-box element in the promoters of Period… read more here.
Keywords: regulatory effects; bmal1; clock bmal1; circadian clock ... See more keywords
Regulation of circadian clock transcriptional output by CLOCK:BMAL1
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DOI: 10.1371/journal.pgen.1007156
Abstract: The mammalian circadian clock relies on the transcription factor CLOCK:BMAL1 to coordinate the rhythmic expression of 15% of the transcriptome and control the daily regulation of biological functions. The recent characterization of CLOCK:BMAL1 cistrome revealed… read more here.
Keywords: transcriptional output; transcription factors; clock; clock bmal1 ... See more keywords
Acute hypoxia induced dysregulation of clock-controlled ovary functions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.1024038
Abstract: High altitudes or exposure to hypoxia leads to female reproductive disorders. Circadian clocks are intrinsic time-tracking systems that enable organisms to adapt to the Earth’s 24-h light/dark cycle, which can be entrained by other environmental… read more here.
Keywords: female reproductive; ovarian circadian; clock bmal1; hypoxia ... See more keywords