NSP-C contributes to the upregulation of CLOCK/BMAL1-mediated transcription
Sign Up to like & getrecommendations! Published in 2018 at "Cytotechnology"
DOI: 10.1007/s10616-018-0266-9
Abstract: The bHLH-PAS transcription factors clock circadian regulator (CLOCK) and brain and muscle ARNT-like protein 1 (BMAL1) play essential roles in the generation of circadian gene expression rhythms through the activation of E-box-mediated transcription. Importantly, circadian… read more here.
Keywords: bmal1; clock bmal1; bmal1 mediated; clock ... See more keywords
Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2114083119
Abstract: Significance Although the circadian clock is essential for regulating the temporal order of physiological functions, circadian oscillation is strictly suppressed in the early-to-mid–stage embryos in mammalian developmental process. The biological significance controlling the suppression of… read more here.
Keywords: clock bmal1; segmentation clock; clock; circadian key ... See more keywords
Regulatory Effects of Clock and Bmal1 on Circadian Rhythmic TLR Expression.
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DOI: 10.1080/08830185.2021.1931170
Abstract: Circadian locomotor output cycles kaput (Clock) and brain and muscle ARNT-like 1 (Bmal1) are two core circadian clock genes. They form a heterodimer that can bind to the E-box element in the promoters of Period… read more here.
Keywords: regulatory effects; bmal1; clock bmal1; circadian clock ... See more keywords
Regulation of circadian clock transcriptional output by CLOCK:BMAL1
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DOI: 10.1371/journal.pgen.1007156
Abstract: The mammalian circadian clock relies on the transcription factor CLOCK:BMAL1 to coordinate the rhythmic expression of 15% of the transcriptome and control the daily regulation of biological functions. The recent characterization of CLOCK:BMAL1 cistrome revealed… read more here.
Keywords: transcriptional output; transcription factors; clock; clock bmal1 ... See more keywords
Acute hypoxia induced dysregulation of clock-controlled ovary functions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.1024038
Abstract: High altitudes or exposure to hypoxia leads to female reproductive disorders. Circadian clocks are intrinsic time-tracking systems that enable organisms to adapt to the Earth’s 24-h light/dark cycle, which can be entrained by other environmental… read more here.
Keywords: female reproductive; ovarian circadian; clock bmal1; hypoxia ... See more keywords