The Circadian Clock Protein CRY1 Is a Negative Regulator of HIF-1α
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DOI: 10.1016/j.isci.2019.02.027
Abstract: Summary The circadian clock and the hypoxia-signaling pathway are regulated by an integrated interplay of positive and negative feedback limbs that incorporate energy homeostasis and carcinogenesis. We show that the negative circadian regulator CRY1 is… read more here.
Keywords: negative regulator; hif; clock protein; circadian clock ... See more keywords
PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells
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DOI: 10.1016/j.stemcr.2017.05.006
Abstract: Summary Tissue integrity requires constant maintenance of a quiescent, yet responsive, population of stem cells. In the skin, hair follicle stem cells (HFSCs) that reside within the bulge maintain tissue homeostasis in response to activating… read more here.
Keywords: core clock; stem; stem cells; clock protein ... See more keywords
PERK links the clock and protein stress in cancer
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DOI: 10.1038/s41556-017-0019-6
Abstract: The unfolded protein response (UPR) regulates cell metabolism and survival in response to stress, yet how the UPR is connected to other signalling pathways is poorly understood. PERK is now shown to regulate Bmal1 and… read more here.
Keywords: clock protein; stress; links clock; cancer ... See more keywords
Effects of circadian clock protein Per1b on zebrafish visual functions
Sign Up to like & getrecommendations! Published in 2018 at "Chronobiology International"
DOI: 10.1080/07420528.2017.1391276
Abstract: ABSTRACT The circadian clock is an endogenous and entrainable time-keeping mechanism with a period of approximately 24 h, operated by transcription/translation feedback loops composed of circadian clock genes and their proteins. The visual system displays… read more here.
Keywords: contrast sensitivity; per1b; clock protein; circadian clock ... See more keywords
Neuronal circadian clock protein oscillations are similar in behaviourally rhythmic forager honeybees and in arrhythmic nurses
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DOI: 10.1098/rsob.170047
Abstract: Internal clocks driving rhythms of about a day (circadian) are ubiquitous in animals, allowing them to anticipate environmental changes. Genetic or environmental disturbances to circadian clocks or the rhythms they produce are commonly associated with… read more here.
Keywords: insects; clock protein; neuronal circadian; circadian clock ... See more keywords
Role of the CLOCK protein in liver detoxification
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DOI: 10.1111/bph.14828
Abstract: Whether and how circadian clock proteins regulate drug detoxification are not known. Here, we have assessed the effects of CLOCK (a core circadian clock protein) on drug metabolism and detoxification. read more here.
Keywords: detoxification; clock protein; protein liver; liver detoxification ... See more keywords
The Circadian Clock Protein CRY2 Promotes MYC Degradation.
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DOI: 10.1158/2159-8290.cd-rw2016-215
Abstract: CRY2 recruits SCFFBXL3 to ubiquitinate MYC, promoting MYC degradation and preventing transformation. read more here.
Keywords: protein cry2; clock protein; circadian clock; myc degradation ... See more keywords
Different Levels of Expression of the Clock Protein PER and the Glial Marker REPO in Ensheathing and Astrocyte-Like Glia of the Distal Medulla of Drosophila Optic Lobe
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.00361
Abstract: Circadian plasticity of the visual system of Drosophila melanogaster depends on functioning of both the neuronal and glial oscillators. The clock function of the former is already quite well-recognized. The latter, however, is much less… read more here.
Keywords: distal medulla; repo; medulla; clock protein ... See more keywords