DNA Methylation Clocks in Aging: Categories, Causes, and Consequences.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.08.008
Abstract: Age-associated changes to the mammalian DNA methylome are well documented and thought to promote diseases of aging, such as cancer. Recent studies have identified collections of individual methylation sites whose aggregate methylation status measures chronological… read more here.
Keywords: methylation; methylation clocks; aging categories; clocks aging ... See more keywords
Epigenetic clocks, aging, and cancer
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abn4009
Abstract: Description Global methylation changes in aging cells affect cancer risk and tissue homeostasis Cancer and aging are accompanied by stereotyped changes to the epigenetic landscape, including progressive loss of DNA methylation over gene-poor genomic regions… read more here.
Keywords: aging cancer; methylation; cancer; epigenetic clocks ... See more keywords