Potential Adverse Effect of Nonsteroidal Anti‐Inflammatory Drugs (NSAIDs) on Bisphosphonate Efficacy: An Exploratory Post Hoc Analysis From a Randomized Controlled Trial of Clodronate
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DOI: 10.1002/jbmr.4548
Abstract: Nonsteroidal anti‐inflammatory drugs (NSAIDs) have been reported to have weak but beneficial effects on bone health, including fracture risk, but many epidemiological studies are likely confounded. We explored the relationship between NSAIDs and fracture risk… read more here.
Keywords: nonsteroidal anti; clodronate; fracture risk; risk ... See more keywords
Influence of clodronate and compressive force on IL-1ß-stimulated human periodontal ligament fibroblasts
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DOI: 10.1007/s00784-019-02930-z
Abstract: Objectives The aim of this study was to investigate in vitro the effect of clodronate on interleukin-1ß (IL-1ß)–stimulated human periodontal ligament fibroblasts (HPdLFs) with the focus on inflammatory factors of orthodontic tooth movement with and… read more here.
Keywords: fold compared; compressive force; timp; force ... See more keywords
Clodronate improves lameness in horses without changing bone turnover markers
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DOI: 10.1111/evj.13011
Abstract: BACKGROUND Clodronate is prescribed to performance horses with lameness. Despite its clinical popularity, little research has been done to understand the effects of clodronate in the horse. OBJECTIVES Our objective was to determine if a… read more here.
Keywords: clodronate; bone; lameness; bone turnover ... See more keywords
Clodronate inhibits alloimmunization against distinct red blood cell alloantigens in mice.
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DOI: 10.1111/trf.16872
Abstract: BACKGROUND Alloimmunization can be a significant barrier to red blood cell (RBC) transfusion. While alloantigen matching protocols hold promise in reducing alloantibody formation, transfusion-dependent patients can still experience RBC alloimmunization and associated complications even when… read more here.
Keywords: transfusion; formation; alloimmunization; clodronate ... See more keywords
Nanomolar clodronate induces adenosine accumulation in the perfused rat mesenteric bed and mesentery-derived endothelial cells
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DOI: 10.3389/fphar.2022.1031223
Abstract: The vesicular nucleotide transporter (VNUT) is critical for sympathetic co-transmission and purinergic transmission maintenance. To examine this proposal, we assessed whether the bisphosphonate clodronate, claimed as a potent in vitro VNUT blocker, modified spontaneous and/or… read more here.
Keywords: nerve terminal; cell; clodronate; endothelial cells ... See more keywords