Potential Adverse Effect of Nonsteroidal Anti‐Inflammatory Drugs (NSAIDs) on Bisphosphonate Efficacy: An Exploratory Post Hoc Analysis From a Randomized Controlled Trial of Clodronate
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DOI: 10.1002/jbmr.4548
Abstract: Nonsteroidal anti‐inflammatory drugs (NSAIDs) have been reported to have weak but beneficial effects on bone health, including fracture risk, but many epidemiological studies are likely confounded. We explored the relationship between NSAIDs and fracture risk… read more here.
Keywords: nonsteroidal anti; clodronate; fracture risk; risk ... See more keywords
Influence of clodronate and compressive force on IL-1ß-stimulated human periodontal ligament fibroblasts
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Oral Investigations"
DOI: 10.1007/s00784-019-02930-z
Abstract: Objectives The aim of this study was to investigate in vitro the effect of clodronate on interleukin-1ß (IL-1ß)–stimulated human periodontal ligament fibroblasts (HPdLFs) with the focus on inflammatory factors of orthodontic tooth movement with and… read more here.
Keywords: fold compared; compressive force; timp; force ... See more keywords
Clodronate improves lameness in horses without changing bone turnover markers
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DOI: 10.1111/evj.13011
Abstract: BACKGROUND Clodronate is prescribed to performance horses with lameness. Despite its clinical popularity, little research has been done to understand the effects of clodronate in the horse. OBJECTIVES Our objective was to determine if a… read more here.
Keywords: clodronate; bone; lameness; bone turnover ... See more keywords
Physicochemical and functional properties of a novel clodronate-containing chelating gel: A comparative in vitro study.
Sign Up to like & getrecommendations! Published in 2024 at "International endodontic journal"
DOI: 10.1111/iej.14185
Abstract: AIM All commercial chelating gels contain EDTA which reacts chemically with sodium hypochlorite (NaOCl). This research aimed to develop a non-EDTA clodronate gel and to measure physicochemical and functional gel properties of the novel and… read more here.
Keywords: clodronate gel; clodronate; gel; file eze ... See more keywords
Clodronate inhibits alloimmunization against distinct red blood cell alloantigens in mice.
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DOI: 10.1111/trf.16872
Abstract: BACKGROUND Alloimmunization can be a significant barrier to red blood cell (RBC) transfusion. While alloantigen matching protocols hold promise in reducing alloantibody formation, transfusion-dependent patients can still experience RBC alloimmunization and associated complications even when… read more here.
Keywords: transfusion; formation; alloimmunization; clodronate ... See more keywords
Low Dose Clodronate Improves Exercise Tolerance, Right Ventricular Function, and Alters Resident Lung Macrophage Phenotypes
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DOI: 10.1182/blood-2024-211429
Abstract: Introduction: Pulmonary hypertension (PH) is a fatal disease that is significantly more prevalent in adults with Sickle Cell Disease (SCD) compared to the general population. The prevalence of PH is rare (3 in 1 million)… read more here.
Keywords: low dose; lung; berk; analysis ... See more keywords
Nanomolar clodronate induces adenosine accumulation in the perfused rat mesenteric bed and mesentery-derived endothelial cells
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1031223
Abstract: The vesicular nucleotide transporter (VNUT) is critical for sympathetic co-transmission and purinergic transmission maintenance. To examine this proposal, we assessed whether the bisphosphonate clodronate, claimed as a potent in vitro VNUT blocker, modified spontaneous and/or… read more here.
Keywords: nerve terminal; cell; clodronate; endothelial cells ... See more keywords