Clofarabine, cytarabine, and mitoxantrone in refractory/relapsed acute myeloid leukemia: High response rates and effective bridge to allogeneic hematopoietic stem cell transplantation
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.2865
Abstract: Clofarabine is active in refractory/relapsed acute myeloid leukemia (AML). In this phase 2 study, we treated 18‐ to 65‐year‐old AML patients refractory to first‐line 3 + 7 daunorubicin/cytarabine induction or relapsing after 3 + 7… read more here.
Keywords: allo hsct; relapsed acute; clofarabine; refractory relapsed ... See more keywords
Molecular and Pharmacological Bladder Cancer Therapy Screening: Discovery of Clofarabine as a Highly Active Compound.
Sign Up to like & getrecommendations! Published in 2022 at "European urology"
DOI: 10.1016/j.eururo.2022.03.009
Abstract: BACKGROUND The heterogeneity of bladder cancers (BCs) is a major challenge for the development of novel therapies. However, given the high rates of recurrence and/or treatment failure, the identification of effective therapeutic strategies is an… read more here.
Keywords: bladder cancer; clofarabine; treatment; cell ... See more keywords
The combination of clofarabine, etoposide, and cyclophosphamide shows limited efficacy as a bridge to transplant for children with refractory acute leukemia: results of a monitored prospective study
Sign Up to like & getrecommendations! Published in 2020 at "Pediatric Hematology and Oncology"
DOI: 10.1080/08880018.2020.1838012
Abstract: Abstract Clofarabine has been shown to effectively induce remission in children with refractory leukemia. We conducted a prospective trial (clinicval.trials.gov NCT01025778) to explore the use of clofarabine-based chemotherapy as a bridge-to-transplant approach. Children with refractory… read more here.
Keywords: clofarabine; children refractory; refractory acute; bridge transplant ... See more keywords
Clofarabine Dosing in a Patient With Acute Myeloid Leukemia on Intermittent Hemodialysis: Case Report and Review of the Literature.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pediatric hematology/oncology"
DOI: 10.1097/mph.0000000000000845
Abstract: Clofarabine containing chemotherapeutic regimens have demonstrated efficacy in the treatment of relapsed refractory acute myeloid leukemia. Nonetheless, there are limited data on the use of clofarabine in patients with renal failure. The present report describes… read more here.
Keywords: myeloid leukemia; intermittent hemodialysis; clofarabine; acute myeloid ... See more keywords
Clofarabine for Lymphodepletion Before CAR-T-Cell Infusion: A Brief Case Report
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000002668
Abstract: Given the shortage of fludarabine, alternative preparative lymphodepleting regimens for CAR-T-cell therapy need to be identified. We present a case of relapsed/refractory B-cell acute lymphoblastic leukemia requiring multiple lines of salvage therapy with persistent extensive… read more here.
Keywords: cell; clofarabine; case; car cell ... See more keywords
Successful clofarabine desensitization in a pediatric patient with acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2021 at "Pediatric Allergy and Immunology"
DOI: 10.1111/pai.13708
Abstract: To the Editor, Clofarabine is a secondgeneration purine nucleoside analogue approved for the treatment of refractory/relapsed pediatric acute leukemias.1,2 Reports of hypersensitivity reactions (HRs) to clofarabine are rare,3,4 and no such cases have been reported… read more here.
Keywords: clofarabine; acute myeloid; desensitization; patient ... See more keywords