Surfactant mediated clofazimine release from nanocellulose-hydrogels
Sign Up to like & getrecommendations! Published in 2019 at "Cellulose"
DOI: 10.1007/s10570-019-02407-y
Abstract: The widely tunable physical and chemical characteristics of hydrogels make them advantageous in biomedical and pharmaceutical applications, yet their hydrophilic nature might discourage their use as drug delivery systems for poorly water soluble molecules. In… read more here.
Keywords: nanocellulose hydrogels; mediated clofazimine; surfactant mediated; clofazimine release ... See more keywords
Improving Stability and Dissolution of Amorphous Clofazimine by Polymer Nano-Coating
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutical Research"
DOI: 10.1007/s11095-019-2584-9
Abstract: PurposeTo inhibit the surface crystallization and enhance the dissolution of the basic amorphous drug clofazimine by polymer nano-coating.MethodsThe free surface of amorphous clofazimine was coated by dip coating in an alginate solution at pH 7. The… read more here.
Keywords: nano coating; polymer; amorphous clofazimine; dissolution ... See more keywords
Optimization of the clofazimine structure leads to a highly water-soluble C3-aminopyridinyl riminophenazine endowed with improved anti-Wnt and anti-cancer activity in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113562
Abstract: Triple-negative breast cancer (TNBC) is a cancer subtype critically dependent upon excessive activation of Wnt pathway. The anti-mycobacterial drug clofazimine is an efficient inhibitor of canonical Wnt signaling in TNBC, reducing tumor cell proliferation in vitro… read more here.
Keywords: wnt; water; tnbc; structure ... See more keywords
Evaluation of Clinical Drug Interaction Potential of Clofazimine Using Static and Dynamic Modeling Approaches
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.117.077834
Abstract: The 2016 World Health Organization treatment recommendations for drug-resistant tuberculosis (DR-TB) positioned clofazimine as a core second-line drug. Being identified as a cytochrome P450 (P450) inhibitor in vitro, a P450-mediated drug interaction may be likely… read more here.
Keywords: drug interaction; interaction potential; drug; potential clofazimine ... See more keywords
Characterization of Clofazimine Metabolism in Human Liver Microsomal Incubation In Vitro
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00565-22
Abstract: Clofazimine [N,5-bis(4-chlorophenyl)-3-[(propane-2-yl)rimino]-3,5-dihydrophenazin-2-amine] is an antimycobacterial agent used as a second-line antituberculosis (anti-TB) drug. Nonetheless, little information is known about the metabolic routes of clofazimine, and the enzymes involved in metabolism. ABSTRACT Clofazimine [N,5-bis(4-chlorophenyl)-3-[(propane-2-yl)rimino]-3,5-dihydrophenazin-2-amine] is an… read more here.
Keywords: clofazimine; metabolism; oxidative metabolites; human liver ... See more keywords
Effectiveness and safety of clofazimine in multidrug-resistant tuberculosis: a nationwide report from Brazil
Sign Up to like & getrecommendations! Published in 2017 at "European Respiratory Journal"
DOI: 10.1183/13993003.02445-2016
Abstract: Although clofazimine is used to treat multidrug-resistant tuberculosis (MDR-TB), there is scant information on its effectiveness and safety. The aim of this retrospective, observational study was to evaluate these factors as well as the tolerability… read more here.
Keywords: safety; versus; multidrug resistant; resistant tuberculosis ... See more keywords
Leprosy drug clofazimine activates peroxisome proliferator-activated receptor-γ and synergizes with imatinib to inhibit chronic myeloid leukemia cells
Sign Up to like & getrecommendations! Published in 2019 at "Haematologica"
DOI: 10.3324/haematol.2018.194910
Abstract: Leukemia stem cells contribute to drug-resistance and relapse in chronic myeloid leukemia (CML) and BCR-ABL1 inhibitor monotherapy fails to eliminate these cells, thereby necessitating alternate therapeutic strategies for patients CML. The peroxisome proliferator-activated receptor-γ (PPARγ)… read more here.
Keywords: peroxisome proliferator; myeloid leukemia; proliferator activated; drug ... See more keywords
Clofazimine for the treatment of tuberculosis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1100488
Abstract: Shorter (6–9 months), fully oral regimens containing new and repurposed drugs are now the first-choice option for the treatment of drug-resistant tuberculosis (DR-TB). Clofazimine, long used in the treatment of leprosy, is one such repurposed… read more here.
Keywords: clofazimine; tuberculosis clofazimine; clofazimine treatment; treatment ... See more keywords
Single Crystal FLIM Characterization of Clofazimine Loaded in Silica-Based Mesoporous Materials and Zeolites
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20122859
Abstract: Clofazimine (CLZ) is an effective antibiotic used against a wide spectrum of Gram-positive bacteria and leprosy. One of its main drawbacks is its poor solubility in water. Silica based materials are used as drug delivery… read more here.
Keywords: crystal flim; single crystal; type aggregates; silica based ... See more keywords
Improving the Antimycobacterial Drug Clofazimine through Formation of Organic Salts by Combination with Fluoroquinolones
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021402
Abstract: This work reports the synthesis, structural and thermal analysis, and in vitro evaluation of the antimicrobial activity of two new organic salts (OSs) derived from the antimycobacterial drug clofazimine and the fluoroquinolones ofloxacin or norfloxacin.… read more here.
Keywords: clofazimine; improving antimycobacterial; organic salts; drug clofazimine ... See more keywords
Encapsulation of Clofazimine by Cyclodextran: Preparation, Characterization, and In Vitro Release Properties
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24108808
Abstract: This study aimed to evaluate and compare the efficacy of cyclodextrans (CIs) and cyclodextrins (CDs) in improving the water solubility of a poorly water-soluble drug, clofazimine (CFZ). Among the evaluated CIs and CDs, CI-9 exhibited… read more here.
Keywords: release properties; clofazimine; cfz; inclusion ... See more keywords