Exploring the structure-permeation relationship of topical tricyclic antidepressants used for skin analgesia.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.03.048
Abstract: The purpose of this study was to evaluate the skin permeation of tricyclic antidepressants (TCAs) with propamine moiety to select candidates for the development of topical analgesics to treat cutaneous pain. We sought to establish… read more here.
Keywords: structure permeation; tcas; permeation; tricyclic antidepressants ... See more keywords
Antidepressants and sexual dysfunction: a history
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Royal Society of Medicine"
DOI: 10.1177/0141076819899299
Abstract: The effect of antidepressants on sex was first noted in 1960 by Frank Ayd, a psychiatrist and the discoverer of amitriptyline, who linked amitriptyline treatment to a sexual dysfunction distinct from the loss of libido… read more here.
Keywords: medicine; dependence; sexual dysfunction; dysfunction ... See more keywords
In Vitro/In Vivo Evaluation of Clomipramine Orodispersible Tablets for the Treatment of Depression and Obsessive-Compulsive Disorder
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DOI: 10.3390/ph16020265
Abstract: The first and only antidepressant drug on the market with solid proof of clinically significant serotonin and noradrenaline reuptake inhibition is clomipramine (CLP). However, significant first-pass metabolism reduces its absorption to less than 62%. It… read more here.
Keywords: clomipramine; vitro vivo; orodispersible tablets; depression ... See more keywords