Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03170-7
Abstract: Deciphering the evolution of cancer cells under therapeutic pressure is a crucial step to understand the mechanisms that lead to treatment resistance. To this end, we analyzed whole-exome sequencing data of eight chronic lymphocytic leukemia (CLL)… read more here.
Keywords: lymphocytic leukemia; dynamics towards; resistance; chronic lymphocytic ... See more keywords
Deciphering clonal dynamics and metastatic routines in a rare patient of synchronous triple-primary tumors and multiple metastases with MPTevol
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac175
Abstract: Multiple primary tumor (MPT) is a special and rare cancer type, defined as more than two primary tumors presenting at the diagnosis in a single patient. The molecular characteristics and tumorigenesis of MPT remain unclear… read more here.
Keywords: triple primary; clonal dynamics; metastatic routines; rare patient ... See more keywords
Clonal hematopoiesis and myeloid malignancies: clonal dynamics and clinical implications
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Hematology"
DOI: 10.1097/moh.0000000000000675
Abstract: Purpose of review Clinical and experimental studies have uncovered relevant clinical implications of clonal hematopoiesis. However, the true magnitude of this process, clonal dynamics over time and mechanisms of progression into overt malignancy remain to… read more here.
Keywords: myeloid malignancies; hematopoiesis; clonal dynamics; clinical implications ... See more keywords
Glioblastoma Stem Cell Clonal Dynamics Drive Intratumor Heterogeneity.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2017-172
Abstract: GBM heterogeneity is primarily driven by the stochastic outcome of GBM stem cell hierarchical growth. read more here.
Keywords: heterogeneity; stem cell; glioblastoma stem; clonal dynamics ... See more keywords