Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03170-7
Abstract: Deciphering the evolution of cancer cells under therapeutic pressure is a crucial step to understand the mechanisms that lead to treatment resistance. To this end, we analyzed whole-exome sequencing data of eight chronic lymphocytic leukemia (CLL)… read more here.
Keywords: lymphocytic leukemia; dynamics towards; resistance; chronic lymphocytic ... See more keywords
Deciphering clonal dynamics and metastatic routines in a rare patient of synchronous triple-primary tumors and multiple metastases with MPTevol
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac175
Abstract: Multiple primary tumor (MPT) is a special and rare cancer type, defined as more than two primary tumors presenting at the diagnosis in a single patient. The molecular characteristics and tumorigenesis of MPT remain unclear… read more here.
Keywords: triple primary; clonal dynamics; metastatic routines; rare patient ... See more keywords
Clonal hematopoiesis and myeloid malignancies: clonal dynamics and clinical implications
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Hematology"
DOI: 10.1097/moh.0000000000000675
Abstract: Purpose of review Clinical and experimental studies have uncovered relevant clinical implications of clonal hematopoiesis. However, the true magnitude of this process, clonal dynamics over time and mechanisms of progression into overt malignancy remain to… read more here.
Keywords: myeloid malignancies; hematopoiesis; clonal dynamics; clinical implications ... See more keywords
Abstract PR011: Comprehensive longitudinal tracking of lung cancer evolutionary clonal dynamics during therapy using circulating tumour DNA
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.canevol23-pr011
Abstract: Background: Outgrowth of resistance cancer cell populations is a common mechanism of therapy failure in oncology. Effective personalised medicine relies on targeting of ubiquitous aberrations; however, tumours are highly heterogenous. Liquid biopsies have the potential… read more here.
Keywords: cancer; therapy; lung cancer; clonal dynamics ... See more keywords
Abstract B082: Clonal dynamics and molecular mechanisms mediating resistance to RAS inhibition
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.pancreatic25-b082
Abstract: RAS inhibitors (RASi) have the potential to change the clinical landscape for pancreatic ductal adenocarcinoma (PDAC) and improve patient survival. Nevertheless, clinical resistance is likely to reduce the long-term benefits of RASi, and combinations that… read more here.
Keywords: resistance ras; resistance; clonal dynamics; molecular mechanisms ... See more keywords
Abstract B106: Elucidating the clonal dynamics and epigenetic regulators of PDAC initiation in inducible neoplastic organoid models
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.pancreatic25-b106
Abstract: Pancreatic intraepithelial neoplasms (PanINs), precursor lesions of pancreatic ductal adenocarcinoma (PDAC) that are abundant healthy individuals, rarely progress to cancer despite universally possessing many of the driver alterations associated with malignancy. Recent single cell profiling… read more here.
Keywords: cancer; clonal dynamics; pdac initiation; elucidating clonal ... See more keywords
Glioblastoma Stem Cell Clonal Dynamics Drive Intratumor Heterogeneity.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2017-172
Abstract: GBM heterogeneity is primarily driven by the stochastic outcome of GBM stem cell hierarchical growth. read more here.
Keywords: heterogeneity; stem cell; glioblastoma stem; clonal dynamics ... See more keywords
Unraveling clonal hematopoiesis of indeterminate potential (CHIP) in cancer: Prevalence, clonal dynamics, and prognostic significance.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.e22524
Abstract: e22524 Background: CHIP prevalence in cancer (CA) patients (pts) is estimated at 30%, its presence being associated to higher risk of therapy-related myeloid neoplasms (TRMN). We hypothesized CHIP may not only predispose to TRMN but… read more here.
Keywords: cancer; clonal dynamics; chip prevalence; chip ... See more keywords