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   Articles with "clonal evolution" as a keyword



Revisiting Clonal Evolution Through the Light of Retrotransposons

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recommendations! Published in 2025 at "Bioessays"

DOI: 10.1002/bies.70078

Abstract: The clonal evolution model provides a framework for understanding the evolution of cancer cells. According to this model, cancer cells accumulate genetic mutations over time, and these mutations are passed down to their descendants, leading… read more here.

Keywords: evolution; cancer; cancer cells; clonal evolution ... See more keywords
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Cytogenetic clonal evolution in myelodysplastic syndromes is associated with inferior prognosis

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recommendations! Published in 2017 at "Cancer"

DOI: 10.1002/cncr.30917

Abstract: The karyotype of bone marrow cells at the time of diagnosis is a strong prognostic parameter for overall survival as well as acute myeloid leukemia (AML) progression in patients with myelodysplastic syndromes (MDS). However, to… read more here.

Keywords: clonal evolution; myelodysplastic syndromes; cytogenetic clonal; syndromes associated ... See more keywords
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Cryptic aberrations may allow more accurate prognostic classification of patients with myelodysplastic syndromes and clonal evolution

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recommendations! Published in 2020 at "Genes"

DOI: 10.1002/gcc.22841

Abstract: The karyotype of bone‐marrow cells at the time of diagnosis is one of the most important prognostic factors in patients with myelodysplastic syndromes (MDS). In some cases, the acquisition of additional genetic aberrations (clonal evolution… read more here.

Keywords: clonal evolution; myelodysplastic syndromes; mds specific; patients myelodysplastic ... See more keywords

DNA damage accumulation and repair defects in FLT3‐ITD acute myeloid leukemia: Implications for clonal evolution and disease progression

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recommendations! Published in 2022 at "Hematological Oncology"

DOI: 10.1002/hon.3076

Abstract: Acute myeloid leukemia is a group of hematological diseases that have a high mortality rate. During the development of this pathology, hematopoietic cells acquire chromosomal rearrangements and multiple genetic mutations, including FLT3‐ITD. FLT3‐ITD is a… read more here.

Keywords: myeloid leukemia; dna damage; clonal evolution; acute myeloid ... See more keywords
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Analysis of cellular models of clonal evolution reveals co-evolution of imatinib and HSP90 inhibitor resistances.

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recommendations! Published in 2020 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2020.11.059

Abstract: Treatment relapse due to clonal evolution was shown to be an independent factor for poor prognosis in advanced stages of chronic myeloid leukemia. Overcoming secondary resistance arising due to clonal evolution is still an unmet… read more here.

Keywords: clonal evolution; hsp90; inhibitor; evolution ... See more keywords

Clonal evolution revealed by next-generation sequencing in a long-term follow-up patient with hypereosinophilia

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recommendations! Published in 2019 at "Leukemia Research Reports"

DOI: 10.1016/j.lrr.2019.04.002

Abstract: Highlights l Next generation sequencing (NGS) applied to establish clonality in a patient with hypereosinophilia.l The first study reported the clonal evolution in a long-term follow-up patient from CEL-NOS stage to MDS and s-AML.l Disease… read more here.

Keywords: clonal evolution; patient hypereosinophilia; next generation; generation sequencing ... See more keywords

Antimicrobial resistance, penicillin-binding protein sequences, and pilus islet carriage in relation to clonal evolution of Streptococcus pneumoniae serotype 19A in Russia, 2002–2013

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recommendations! Published in 2017 at "Epidemiology and Infection"

DOI: 10.1017/s0950268817000541

Abstract: SUMMARY Clonal changes of serotype 19A pneumococci have been appreciated in conjunction with growing prevalence of this serotype after implementation of the seven-valent pneumococcal conjugate vaccine (PCV7). In the present study, we characterized serotype 19A… read more here.

Keywords: clonal evolution; 2002 2013; islet carriage; serotype 19a ... See more keywords

De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia

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recommendations! Published in 2018 at "Nature Communications"

DOI: 10.1038/s41467-018-04180-1

Abstract: Activating signaling mutations are common in acute leukemia with KMT2A (previously MLL) rearrangements (KMT2A-R). These mutations are often subclonal and their biological impact remains unclear. Using a retroviral acute myeloid mouse leukemia model, we demonstrate… read more here.

Keywords: signaling mutations; clonal evolution; kmt2a mllt3; kmt2a ... See more keywords

ClonEvol: clonal ordering and visualization in cancer sequencing

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recommendations! Published in 2017 at "Annals of Oncology"

DOI: 10.1093/annonc/mdx517

Abstract: Background Reconstruction of clonal evolution is critical for understanding tumor progression and implementing personalized therapies. This is often done by clustering somatic variants based on their cellular prevalence estimated via bulk tumor sequencing of multiple… read more here.

Keywords: ordering visualization; clonal evolution; clonevol; clonal ordering ... See more keywords

clevRvis: visualization techniques for clonal evolution

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recommendations! Published in 2022 at "GigaScience"

DOI: 10.1093/gigascience/giad020

Abstract: Abstract Background A thorough analysis of clonal evolution commonly requires integration of diverse sources of data (e.g., karyotyping, next-generation sequencing, and clinical information). Subsequent to actual reconstruction of clonal evolution, detailed analysis and interpretation of… read more here.

Keywords: clonal evolution; techniques clonal; visualization techniques; analysis ... See more keywords
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Chemotherapy after PD-1 inhibitors in relapsed/refractory Hodgkin lymphoma: Outcomes and clonal evolution dynamics.

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recommendations! Published in 2022 at "British journal of haematology"

DOI: 10.1111/bjh.18183

Abstract: Checkpoint inhibitors (CPIs) are routinely employed in relapsed/refractory classical Hodgkin lymphoma. Nonetheless, persistent long-term responses are uncommon, and one-third of patients are refractory. Several reports have suggested that treatment with CPIs may re-sensitize patients to… read more here.

Keywords: chemotherapy; hodgkin lymphoma; clonal evolution; evolution ... See more keywords