Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17898-8
Abstract: Clonal expansions occur in the persistent HIV reservoir as shown by the duplication of proviral integration sites. However, the source of the proliferation of HIV-infected cells remains unclear. Here, we analyze the TCR repertoire of… read more here.
Keywords: clonal expansions; reservoir; hiv; hiv reservoir ... See more keywords
Somatic mutations and clonal expansions in paroxysmal nocturnal hemoglobinuria.
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DOI: 10.1053/j.seminhematol.2022.08.004
Abstract: Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell disorder caused by a mutation of the X-linked PIGA gene, resulting in a deficient expression of glycosylphosphatidylinositol (GPI)-anchored proteins. While large clonal expansions of… read more here.
Keywords: gpi; gpi hspcs; nocturnal hemoglobinuria; paroxysmal nocturnal ... See more keywords
Persistent Large Granular Lymphocyte Clonal Expansions: “The Root of Many Evils”—And of Some Goodness
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DOI: 10.3390/cancers14051340
Abstract: Simple Summary Large granular lymphocyte leukemia (LGLL) is a chronic disorder of either mature T or NK lymphocytes. As clonal expansions of the immune system cells, difficulties in the distinction between a true neoplasia and… read more here.
Keywords: clonal expansions; granular lymphocyte; persistent large; large granular ... See more keywords