Re: "Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease".
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31169
Abstract: Studies of somatic mutations have historically focused on those occurring during carcinogenesis, but recent research suggests functional mutations can accumulate in the absence of cancer. Zhu and colleagues recently published an extensive analysis of exome… read more here.
Keywords: hepatic clonal; mutations increase; increase hepatic; somatic mutations ... See more keywords
Clonal fitness inferred from time-series modelling of single-cell cancer genomes.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-03648-3
Abstract: Progress in defining genomic fitness landscapes in cancer, especially those defined by copy number alterations (CNAs), has been impeded by lack of time-series single-cell sampling of polyclonal populations and temporal statistical models1-7. Here we generated… read more here.
Keywords: single cell; time series; fitness; cancer ... See more keywords