Full spectrum of clonal haematopoiesis‐driver mutations in chronic heart failure and their associations with mortality
Sign Up to like & getrecommendations! Published in 2021 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13297
Abstract: Somatic mutations in haematopoietic stem cells can lead to the clonal expansion of mutated blood cells, known as clonal haematopoiesis (CH). Mutations in the most prevalent driver genes DNMT3A and TET2 with a variant allele… read more here.
Keywords: clonal haematopoiesis; chronic heart; heart; heart failure ... See more keywords
Clonal haematopoiesis is associated with higher mortality in patients with cardiogenic shock
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.2588
Abstract: Cardiogenic shock (CS) with variable systemic inflammation may be responsible for patient heterogeneity and the exceedingly high mortality rate. Cardiovascular events have been associated with clonal haematopoiesis (CH) where specific gene mutations in haematopoietic stem… read more here.
Keywords: clonal haematopoiesis; mortality; haematopoiesis associated; cardiogenic shock ... See more keywords
Biomarkers in clonal haematopoiesis of indeterminate potential (CHIP) linking cardiovascular diseases, myeloid neoplasms and inflammation
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Hematology"
DOI: 10.1007/s00277-025-06244-x
Abstract: There is increasing evidence that points to ubiquity of clonal haematopoiesis of indeterminate potential (CHIP) especially with rising age. CHIP has been associated with a multitude of inflammatory, cardiovascular and malignant conditions. In this review… read more here.
Keywords: haematopoiesis indeterminate; potential chip; indeterminate potential; clonal haematopoiesis ... See more keywords
"Reversible" myelodysplastic syndrome or ineffectual clonal haematopoiesis? - add(6p) myeloid neoplasm with a spontaneous cytogenetic remission.
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia research"
DOI: 10.1016/j.leukres.2018.08.010
Abstract: Cytotoxic chemotherapy has inherent mutagenic potential and alters the bone marrow microenvironment after therapy. In some cases, this potentiates expansion of an aberrant clone and may lead to a therapy-related myeloid neoplasm if the clone… read more here.
Keywords: myeloid neoplasm; clonal haematopoiesis; cytogenetic remission; spontaneous cytogenetic ... See more keywords
Clonal haematopoiesis of emerging significance.
Sign Up to like & getrecommendations! Published in 2021 at "Pathology"
DOI: 10.1016/j.pathol.2021.02.005
Abstract: Clonal haematopoiesis (CH) is a ubiquitous feature of aging and provides mechanistic insight into the inextricable relationship between chronic inflammation and age-related diseases. Although CH confers a cumulative risk of subsequent haematological malignancy, particularly myeloid… read more here.
Keywords: haematopoiesis emerging; clonal haematopoiesis; risk; haematopoiesis ... See more keywords
Clonal haematopoiesis of indeterminate potential predicts recurrence of atrial arrhythmias after surgical ablation for atrial fibrillation
Sign Up to like & getrecommendations! Published in 2024 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehae666.584
Abstract: Clonal haematopoiesis of indeterminate potential (CHIP), characterized by the presence of somatic blood cell clone expanding without other haematological abnormalities, was recently shown to be significantly associated with the development and progression of atrial fibrillation… read more here.
Keywords: ablation; atrial arrhythmias; surgical ablation; clonal haematopoiesis ... See more keywords
The emerging role of clonal haematopoiesis in the pathogenesis of dilated cardiomyopathy
Sign Up to like & getrecommendations! Published in 2024 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehae682
Abstract: Graphical Abstract Graphical Abstract Clonal haematopoiesis in the pathogenesis of dilated cardiomyopathy. CH, clonal haematopoiesis; VAF, variant allele frequency. read more here.
Keywords: dilated cardiomyopathy; pathogenesis dilated; haematopoiesis pathogenesis; haematopoiesis ... See more keywords
Recent advances in understanding clonal haematopoiesis in aplastic anaemia
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Haematology"
DOI: 10.1111/bjh.14510
Abstract: Acquired aplastic anaemia (AA) is an immune‐mediated bone marrow failure disorder inextricably linked to clonal haematopoiesis. The majority of AA patients have somatic mutations and/or structural chromosomal abnormalities detected as early as at diagnosis. In… read more here.
Keywords: clonal haematopoiesis; advances understanding; haematopoiesis; aplastic anaemia ... See more keywords
Clonal haematopoiesis of indeterminate potential among cancer survivors exposed to myelotoxic chemotherapy
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Haematology"
DOI: 10.1111/bjh.15861
Abstract: genetic subtype. Fig S1. (A) Bacterial artificial chromosome (BACs) used for fluorescence in situ hybridization DUSP22 break-apart assays with hg 19 co-ordinates. (B) Partial karyotype showing the expected site of chromosomal localization (6p25.3) on normal… read more here.
Keywords: clonal haematopoiesis; negative neg; alk; break apart ... See more keywords
Clonal haematopoiesis as a risk factor for therapy‐related myeloid neoplasms in patients with chronic lymphocytic leukaemia treated with chemo‐(immuno)therapy
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18129
Abstract: Clonal haematopoiesis of indeterminate potential (CHIP) may predispose for the development of therapy‐related myeloid neoplasms (t‐MN). Using target next‐generation sequencing (t‐NGS) panels and digital droplet polymerase chain reactions (ddPCR), we studied the myeloid gene mutation… read more here.
Keywords: related myeloid; therapy; clonal haematopoiesis; therapy related ... See more keywords
Association of clonal haematopoiesis with recurrent venous thromboembolism: A case–control study
Sign Up to like & getrecommendations! Published in 2024 at "British Journal of Haematology"
DOI: 10.1111/bjh.19871
Abstract: Venous thromboembolism (VTE) is the third most common cardiovascular disease. Clonal haematopoiesis (CH) is linked to cardiovascular disease risk, but its potential association with VTE remains poorly understood. We assessed the prevalence of CH in… read more here.
Keywords: association; clonal haematopoiesis; venous thromboembolism; vte ... See more keywords