Full spectrum of clonal haematopoiesis‐driver mutations in chronic heart failure and their associations with mortality
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DOI: 10.1002/ehf2.13297
Abstract: Somatic mutations in haematopoietic stem cells can lead to the clonal expansion of mutated blood cells, known as clonal haematopoiesis (CH). Mutations in the most prevalent driver genes DNMT3A and TET2 with a variant allele… read more here.
Keywords: clonal haematopoiesis; chronic heart; heart; heart failure ... See more keywords
Clonal haematopoiesis is associated with higher mortality in patients with cardiogenic shock
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.2588
Abstract: Cardiogenic shock (CS) with variable systemic inflammation may be responsible for patient heterogeneity and the exceedingly high mortality rate. Cardiovascular events have been associated with clonal haematopoiesis (CH) where specific gene mutations in haematopoietic stem… read more here.
Keywords: clonal haematopoiesis; mortality; haematopoiesis associated; cardiogenic shock ... See more keywords
"Reversible" myelodysplastic syndrome or ineffectual clonal haematopoiesis? - add(6p) myeloid neoplasm with a spontaneous cytogenetic remission.
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DOI: 10.1016/j.leukres.2018.08.010
Abstract: Cytotoxic chemotherapy has inherent mutagenic potential and alters the bone marrow microenvironment after therapy. In some cases, this potentiates expansion of an aberrant clone and may lead to a therapy-related myeloid neoplasm if the clone… read more here.
Keywords: myeloid neoplasm; clonal haematopoiesis; cytogenetic remission; spontaneous cytogenetic ... See more keywords
Clonal haematopoiesis of emerging significance.
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DOI: 10.1016/j.pathol.2021.02.005
Abstract: Clonal haematopoiesis (CH) is a ubiquitous feature of aging and provides mechanistic insight into the inextricable relationship between chronic inflammation and age-related diseases. Although CH confers a cumulative risk of subsequent haematological malignancy, particularly myeloid… read more here.
Keywords: haematopoiesis emerging; clonal haematopoiesis; risk; haematopoiesis ... See more keywords
Recent advances in understanding clonal haematopoiesis in aplastic anaemia
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DOI: 10.1111/bjh.14510
Abstract: Acquired aplastic anaemia (AA) is an immune‐mediated bone marrow failure disorder inextricably linked to clonal haematopoiesis. The majority of AA patients have somatic mutations and/or structural chromosomal abnormalities detected as early as at diagnosis. In… read more here.
Keywords: clonal haematopoiesis; advances understanding; haematopoiesis; aplastic anaemia ... See more keywords
Clonal haematopoiesis of indeterminate potential among cancer survivors exposed to myelotoxic chemotherapy
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Haematology"
DOI: 10.1111/bjh.15861
Abstract: genetic subtype. Fig S1. (A) Bacterial artificial chromosome (BACs) used for fluorescence in situ hybridization DUSP22 break-apart assays with hg 19 co-ordinates. (B) Partial karyotype showing the expected site of chromosomal localization (6p25.3) on normal… read more here.
Keywords: clonal haematopoiesis; negative neg; alk; break apart ... See more keywords
Clonal haematopoiesis as a risk factor for therapy‐related myeloid neoplasms in patients with chronic lymphocytic leukaemia treated with chemo‐(immuno)therapy
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18129
Abstract: Clonal haematopoiesis of indeterminate potential (CHIP) may predispose for the development of therapy‐related myeloid neoplasms (t‐MN). Using target next‐generation sequencing (t‐NGS) panels and digital droplet polymerase chain reactions (ddPCR), we studied the myeloid gene mutation… read more here.
Keywords: related myeloid; therapy; clonal haematopoiesis; therapy related ... See more keywords
Clonal haematopoiesis of indeterminate potential and impaired kidney function—A Danish general population study with 11 years follow‐up
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Haematology"
DOI: 10.1111/ejh.13845
Abstract: The myeloproliferative neoplasms are associated with chronic kidney disease but whether clonal haematopoiesis of indeterminate potential (CHIP) is associated with impaired kidney function is unknown. In the Danish General Suburban Population Study (N = 19 958)… read more here.
Keywords: kidney; kidney function; clonal haematopoiesis; chip ... See more keywords
THU0026 CLONAL HAEMATOPOIESIS ASSOCIATED SOMATIC MUTATIONS IN RHEUMATOID ARTHRITIS
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DOI: 10.1136/annrheumdis-2020-eular.5568
Abstract: Background: Clonal haematopoiesis of indeterminate potential (CHIP) occurs when somatic mutations arise in myeloid neoplasia driver genes of haematopoietic progenitor cells, in the absence of overt cytopenia or dysplasia. The prevalence of CHIP increases with… read more here.
Keywords: none declared; clonal haematopoiesis; rheumatoid arthritis; somatic mutations ... See more keywords
Emerging patterns in clonal haematopoiesis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2019-205851
Abstract: Clonal haematopoiesis (CH) is defined by the presence of acquired mutations and/or cytogenetic abnormalities in haematopoietic cells. By definition, these premalignant clones do not meet criteria for haematopoietic neoplasms listed in the Revised Fourth Edition… read more here.
Keywords: clonal haematopoiesis; emerging patterns; patterns clonal; haematopoiesis ... See more keywords