TET2-Driven Clonal Hematopoiesis and Response to Canakinumab: An Exploratory Analysis of the CANTOS Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2022.0386
Abstract: Importance Clonal hematopoiesis of indeterminate potential (CHIP) is associated with increased risk of atherosclerotic cardiovascular disease, and mouse experiments suggest that CHIP related to Tet2 loss of function in myeloid cells accelerates atherosclerosis via augmented… read more here.
Keywords: trial; randomized clinical; clinical trial; chip ... See more keywords
Clinical Importance of Clonal Hematopoiesis in Metastatic Gastrointestinal Tract Cancers
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.54221
Abstract: Key Points Question To what extent is clonal hematopoiesis (CH) associated with treatment response and toxicity among patients with metastatic cancer who receive chemotherapy or immune checkpoint blockade? Findings In this cohort study of 633… read more here.
Keywords: metastatic gastrointestinal; hematopoiesis metastatic; importance clonal; clinical importance ... See more keywords
Remarkable stability in clonal hematopoiesis involving leukemia‐driver genes in patients without underlying myeloid neoplasms
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26297
Abstract: PD1/PDL1 in malignant cells and tumor-associated macrophages in PBL, but also a worse survival associated with PD1/PDL1 expression. Herein, we report the first case of PBL treated with the anti-PD1 monoclonal antibody pembrolizumab at standard… read more here.
Keywords: hematopoiesis involving; clonal hematopoiesis; stability clonal; leukemia driver ... See more keywords
Flow Cytometry Analysis of Hematopoietic Stem/Progenitor Cells and Mature Blood Cell Subsets in Atherosclerosis.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1924-7_36
Abstract: Advancing age causes physiologic decline in tissue function. In the hematopoietic system this manifests as a progressive reduction in blood or immune cell function and clonal hematopoiesis, where a mutated hematopoietic stem cell can dominate blood cell… read more here.
Keywords: blood; cell; clonal hematopoiesis; hematopoietic stem ... See more keywords
Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Disease
Sign Up to like & getrecommendations! Published in 2020 at "Current Oncology Reports"
DOI: 10.1007/s11912-020-00955-2
Abstract: Purpose of Review The purpose of this review article is to summarize the preclinical and clinical evidence supporting the notion of clonal hematopoiesis of indeterminate potential (CHIP), highlight current knowledge gap, and provide future directions.… read more here.
Keywords: risk; clonal hematopoiesis; hematopoiesis indeterminate; chip ... See more keywords
Clonal hematopoiesis: Pre‐cancer PLUS
Sign Up to like & getrecommendations! Published in 2019 at "Advances in Cancer Research"
DOI: 10.1016/bs.acr.2018.12.003
Abstract: ABSTRACT Clonal hematopoiesis is a common, age‐related process in which a somatically mutated hematopoietic precursor gives rise to a genetically distinct subpopulation in the blood. This phenomenon has been observed in populations across the globe… read more here.
Keywords: hematopoiesis; clonal hematopoiesis; increased risk; cancer ... See more keywords
Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.01.049
Abstract: Clonal hematopoiesis, a condition in which individual hematopoietic stem cell clones generate a disproportionate fraction of blood leukocytes, correlates with higher risk for cardiovascular disease. The mechanisms behind this association are incompletely understood. Here, we… read more here.
Keywords: clonal hematopoiesis; stem cell; cell; cell proliferation ... See more keywords
THE ASSOCIATION OF CLONAL HEMATOPOIESIS OF INDETERMINATE POTENTIAL WITH CHRONIC ISCHEMIC HEART FAILURE
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.352
Abstract: Cardiovascular diseases (CVD) are one of the leading causes of death. Beside established risk factors, clonal hematopoiesis of indeterminate potential (CHIP) is associated with a higher risk of CVD. CHIP is defined as the expansion… read more here.
Keywords: chronic ischemic; ischemic heart; indeterminate potential; clonal hematopoiesis ... See more keywords
3154 – RHESUS MACAQUES AS NATURAL MODELS FOR AGE-RELATED CLONAL HEMATOPOIESIS
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.09.161
Abstract: Clonal hematopoiesis (CH) describes the clonal expansion of blood cells derived from hematopoietic stem/progenitor cell (HSPC) sharing the same somatic mutations. Recent large deep sequencing studies revealed that CH somatic mutations are prevalent in peripheral… read more here.
Keywords: 3154 rhesus; clonal hematopoiesis; age; somatic mutations ... See more keywords
Clonal Hematopoiesis of Indeterminate Potential Reshapes Age-Related CVD: JACC Review Topic of the Week.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2019.05.045
Abstract: The incidence of cardiovascular diseases increases with age and is also correlated with increased inflammatory burden. Recently, human genetics provided a new paradigm linking aging, inflammation, and atherosclerotic cardiovascular disease (ASCVD). Next-generation genetic sequencing of… read more here.
Keywords: clonal hematopoiesis; age; indeterminate potential; hematopoiesis indeterminate ... See more keywords
Sowing the Seeds of Clonal Hematopoiesis.
Sign Up to like & getrecommendations! Published in 2020 at "Cell stem cell"
DOI: 10.1016/j.stem.2020.07.011
Abstract: As humans age, hematopoietic stem cells (HSCs) occasionally acquire mutations in genes including DNMT3A that enable them to outcompete other HSCs and increase leukemia risk. In this issue of Cell Stem Cell, Tovy et al. (2020)… read more here.
Keywords: sowing seeds; seeds clonal; clonal hematopoiesis; stem ... See more keywords