Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation
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DOI: 10.1158/2159-8290.cd-21-1631
Abstract: Loss-of-function alterations in LZTR1, a Cullin-3 RING E3 ubiquitin ligase adapter, and impaired ubiquitin-mediated degradation of RAS proteins via mutations in RIT1 drive clonal hematopoietic transformation. read more here.
Keywords: hematopoietic transformation; impaired proteolysis; ras proteins; proteolysis noncanonical ... See more keywords
The Clonal Hematopoietic Spectrum of Down Syndrome and ML-DS
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DOI: 10.1182/blood-2018-99-120168
Abstract: Introduction: Children with Down syndrome (DS) have a 150-fold higher risk of developing myeloid leukemia (ML-DS) (Wechsler J, Nat Gen 2002). Ten percent (10%) of DS children are also predisposed to developing a preleukemic self-limiting… read more here.
Keywords: fat1 setd2; nat gen; tmd; clonal hematopoietic ... See more keywords