Identification of KRAS G12V associated clonal neoantigens and immune microenvironment in long-term survival of pancreatic adenocarcinoma
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DOI: 10.1007/s00262-021-03012-4
Abstract: To investigate the molecular characteristics in tumor immune microenvironment that affect long-term survival of patients with pancreatic adenocarcinoma (PAAD). The tumor related genetic features of a female PAAD patient (over 13-year survival) who suffered from… read more here.
Keywords: long term; immune microenvironment; clonal neoantigens; term survival ... See more keywords
Indication-specific tumor evolution and its impact on neoantigen targeting and biomarkers for individualized cancer immunotherapies
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003001
Abstract: Background Individualized neoantigen-specific immunotherapy (iNeST) requires robustly expressed clonal neoantigens for efficacy, but tumor mutational heterogeneity, loss of neoantigen expression, and variable tissue sampling present challenges. It is assumed that clonal neoantigens are preferred targets… read more here.
Keywords: impact neoantigen; neoantigen targeting; clonal neoantigens; cancer ... See more keywords