Mitigating Clonal Variation in Recombinant Mammalian Cell Lines.
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DOI: 10.1016/j.tibtech.2019.02.007
Abstract: Mammalian expression platforms are primary production systems for therapeutic proteins that require complex post-translational modifications. Current processes used for developing recombinant mammalian cell lines generate clonal cell lines with high phenotypic heterogeneity, which has puzzled… read more here.
Keywords: cell lines; mammalian cell; clonal variation; cell ... See more keywords