Next-generation sequencing of immunoglobulin gene rearrangements for clonality assessment: a technical feasibility study by EuroClonality-NGS
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-019-0508-7
Abstract: One of the hallmarks of B lymphoid malignancies is a B cell clone characterized by a unique footprint of clonal immunoglobulin (IG) gene rearrangements that serves as a diagnostic marker for clonality assessment. The EuroClonality/BIOMED-2… read more here.
Keywords: euroclonality ngs; feasibility study; clonality assessment; gene ... See more keywords
T cell clonality assessment: past, present and future
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2017-204761
Abstract: T cell clonality testing has important clinical and research value, providing a specific and reproducible assessment of clonal diversity in T cell proliferations. Here we review the conceptual foundations of T cell clonality assays, including… read more here.
Keywords: cell clonality; assessment past; pathology; clonality assessment ... See more keywords
Molecular Diagnosis of T-cell Lymphoma: A correlative study of PCR-based T-cell clonality assessment and targeted NGS.
Sign Up to like & getrecommendations! Published in 2021 at "Blood advances"
DOI: 10.1182/bloodadvances.2021005249
Abstract: Immunomorphological diagnosis of T-cell lymphomas (TCL) may be challenging, especially on needle biopsies. Multiplex polymerase chain reaction (PCR) assays to assess T-cell receptor (TCR) gene rearrangements are now widely used to detect T-cell clones and… read more here.
Keywords: diagnosis cell; diagnosis; cell clonality; pcr ... See more keywords