A role for peroxisome proliferator-activated receptor α in anticonvulsant activity of docosahexaenoic acid against seizures induced by pentylenetetrazole
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.05.042
Abstract: Docosahexaenoic acid (DHA) is the most bioactive fatty acid in the brain with well-known biological effects. Peroxisome proliferator-activated receptors (PPARs) underlie some therapeutic effects of DHA such as anti-inflammation, anti-apoptosis and immune regulation. We investigated… read more here.
Keywords: peroxisome proliferator; docosahexaenoic acid; proliferator activated; clonic seizures ... See more keywords
Open‐label study to investigate the safety and efficacy of adjunctive perampanel in pediatric patients (4 to
Sign Up to like & getrecommendations! Published in 2020 at "Epilepsia"
DOI: 10.1111/epi.16413
Abstract: Study 311 (NCT02849626) was a global, multicenter, open‐label, single‐arm study that assessed safety, tolerability, pharmacokinetics, and pharmacokinetics/pharmacodynamics of once‐daily adjunctive perampanel oral suspension in pediatric patients (aged 4 to read more here.
Keywords: adjunctive perampanel; tonic clonic; study; clonic seizures ... See more keywords
Predictors of focal to bilateral tonic‐clonic seizures during long‐term video‐EEG monitoring
Sign Up to like & getrecommendations! Published in 2020 at "Epilepsia"
DOI: 10.1111/epi.16454
Abstract: To determine predictors of focal to bilateral tonic‐clonic seizures (FBTCS) during video–electroencephalography (EEG) monitoring (VEM). read more here.
Keywords: tonic clonic; predictors focal; eeg monitoring; clonic seizures ... See more keywords
Focal to bilateral tonic–clonic seizures are associated with widespread network abnormality in temporal lobe epilepsy
Sign Up to like & getrecommendations! Published in 2021 at "Epilepsia"
DOI: 10.1111/epi.16819
Abstract: Our objective was to identify whether the whole‐brain structural network alterations in patients with temporal lobe epilepsy (TLE) and focal to bilateral tonic–clonic seizures (FBTCS) differ from alterations in patients without FBTCS. read more here.
Keywords: lobe epilepsy; tonic clonic; clonic seizures; temporal lobe ... See more keywords
Dynamic Susceptibility Contrast Enhanced (DSC) MRI Perfusion and Plasma Cytokine Levels in Patients after Tonic-clonic Seizures
Sign Up to like & getrecommendations! Published in 2017 at "Radiology and Oncology"
DOI: 10.1515/raon-2017-0031
Abstract: Abstract Background Inflammatory events in brain parenchyma and glial tissue are involved in epileptogenesis. Blood concentration of cytokines is shown to be elevated after tonic-clonic seizures. As a result of inflammation, blood-brain barrier leakage occurs.… read more here.
Keywords: perfusion; tonic clonic; mri perfusion; clonic seizures ... See more keywords
Bilateral Quadriceps Tendon Rupture and Femoral Neck Fracture After Generalized Tonic-Clonic Seizures
Sign Up to like & getrecommendations! Published in 2022 at "JBJS Case Connector"
DOI: 10.2106/jbjs.cc.20.00062
Abstract: Case: We report on a 19-year-old male renal transplant patient with multiple medical issues who sustained simultaneous bilateral quadriceps tendon ruptures and bilateral femoral neck fractures after 2 generalized tonic-clonic seizures. The quadriceps tendon ruptures… read more here.
Keywords: femoral neck; clonic seizures; tonic clonic; quadriceps tendon ... See more keywords
Multimodal Data and Machine Learning for Detecting Specific Biomarkers in Pediatric Epilepsy Patients With Generalized Tonic-Clonic Seizures
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2018.01038
Abstract: Previous neuroimaging studies of epilepsy with generalized tonic-clonic seizures (GTCS) focus mainly on adults. However, the neural mechanisms that underline this type of epilepsy remain unclear, especially for children. The aim of the present study… read more here.
Keywords: epilepsy; tonic clonic; right thalamus; clonic seizures ... See more keywords
White matter alterations in focal to bilateral tonic-clonic seizures
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.972590
Abstract: We examined the white matter of patients with and without focal to bilateral tonic-clonic seizures (FBTCS), and control participants. A neural network based tract segmentation model (Tractseg) was used to isolate tract-specific, track-weighted tensor-based measurements… read more here.
Keywords: matter; clonic seizures; bilateral tonic; white matter ... See more keywords
Amplitude of Low-Frequency Fluctuation With Different Clinical Outcomes in Patients With Generalized Tonic–Clonic Seizures
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.847366
Abstract: Background Generalized tonic–clonic seizures (GTCS) are associated with significant disability and sudden unexpected death when they cannot be controlled. We aimed to explore the underlying neural substrate of the different responses to antiseizure drugs between… read more here.
Keywords: generalized tonic; clonic seizures; gyrus; amplitude low ... See more keywords
EEG Network Analysis in Epilepsy with Generalized Tonic–Clonic Seizures Alone
Sign Up to like & getrecommendations! Published in 2022 at "Brain Sciences"
DOI: 10.3390/brainsci12111574
Abstract: Many contradictory theories regarding epileptogenesis in idiopathic generalized epilepsy have been proposed. This study aims to define the network that takes part in the formation of the spike-wave discharges in patients with generalized tonic–clonic seizures… read more here.
Keywords: generalized tonic; network; clonic seizures; analysis ... See more keywords