Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells
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DOI: 10.18632/oncotarget.25508
Abstract: Human carbonic anhydrase (CA) IX has emerged as a promising anticancer target and a diagnostic biomarker for solid hypoxic tumors. Novel fluorinated CA IX inhibitors exhibited up to 50 pM affinity towards the recombinant human… read more here.
Keywords: carbonic anhydrase; acidification; novel fluorinated; clonogenic survival ... See more keywords