Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25508
Abstract: Human carbonic anhydrase (CA) IX has emerged as a promising anticancer target and a diagnostic biomarker for solid hypoxic tumors. Novel fluorinated CA IX inhibitors exhibited up to 50 pM affinity towards the recombinant human… read more here.
Keywords: carbonic anhydrase; acidification; novel fluorinated; clonogenic survival ... See more keywords
A 3D Co-Culture Scaffold Approach to Assess Spatially Fractionated Radiotherapy Bystander and Abscopal Immune Effects on Clonogenic Survival
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26094436
Abstract: Spatially fractionated radiotherapy (SFRT) offers a promising approach for debulking large tumors by delivering high-dose radiation to a fraction of the tumor volume. However, the complex tumor microenvironment necessitates models beyond traditional 2D cultures and… read more here.
Keywords: effect; spatially fractionated; culture; clonogenic survival ... See more keywords
Alpha-Mangostin Enhances Radiosensitivity in HeLa Cervical Cancer Cells
Sign Up to like & getrecommendations! Published in 2025 at "Scientia Pharmaceutica"
DOI: 10.3390/scipharm93040054
Abstract: Radiotherapy (RT) is a standard treatment for cervical cancer, but its efficacy is often limited by tumor hypoxia and low radiosensitivity. Radiosensitizers that enhance RT without dose escalation are therefore of clinical interest. Alpha-mangostin (AM),… read more here.
Keywords: cervical cancer; radiosensitivity; clonogenic survival; alpha mangostin ... See more keywords