Aspirin vs Clopidogrel for Long-term Maintenance After Coronary Stenting in Patients With Diabetes: A Post Hoc Analysis of the HOST-EXAM Trial.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2023.0592
Abstract: Importance Selecting the optimal antiplatelet agent in patients who have received percutaneous coronary intervention is especially important in those with diabetes due to the heightened risk of ischemic events in this population. Studies on the… read more here.
Keywords: long term; term maintenance; clopidogrel; trial ... See more keywords
Oral antiplatelet agents for the management of acute coronary syndromes: A review for nurses and allied healthcare professionals
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Association of Nurse Practitioners"
DOI: 10.1002/2327-6924.12438
Abstract: Purpose We review the use of oral antiplatelet (OAP) therapies in acute coronary syndrome (ACS) management for nurse practitioners (NPs), focusing on current guideline recommendations. Data sources Treatment guidelines and clinical articles from PubMed. Conclusions… read more here.
Keywords: clopidogrel; ticagrelor; antiplatelet; management ... See more keywords
Influence of smoking on the antiplatelet effect of clopidogrel differs according to clopidogrel dose: Insights from the GRAVITAS trial
Sign Up to like & getrecommendations! Published in 2017 at "Catheterization and Cardiovascular Interventions"
DOI: 10.1002/ccd.26428
Abstract: To examine the influence of smoking on the antiplatelet effect of clopidogrel following percutaneous coronary intervention (PCI). read more here.
Keywords: clopidogrel; effect clopidogrel; influence smoking; antiplatelet effect ... See more keywords
Predictors and long‐term outcomes of in‐hospital switching from clopidogrel to ticagrelor among patients with acute coronary syndrome undergoing percutaneous coronary intervention
Sign Up to like & getrecommendations! Published in 2022 at "Catheterization and Cardiovascular Interventions"
DOI: 10.1002/ccd.30089
Abstract: This study evaluated clinical outcomes of switching from clopidogrel to ticagrelor in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). The clinical benefit of in‐hospital switching from clopidogrel to ticagrelor in these… read more here.
Keywords: clopidogrel ticagrelor; ticagrelor; clopidogrel; switching ticagrelor ... See more keywords
Comparative Effectiveness of Ticagrelor, Prasugrel, and Clopidogrel for Secondary Prophylaxis in Acute Coronary Syndrome: A Propensity Score‐Matched Cohort Study
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2797
Abstract: Comparative effectiveness evaluation of newer P2Y12 inhibitors (prasugrel and ticagrelor) compared with clopidogrel after acute coronary syndrome (ACS) is limited in real‐world US populations. The objective of this study was to evaluate cardiovascular events based… read more here.
Keywords: ticagrelor; prasugrel clopidogrel; clopidogrel; comparative effectiveness ... See more keywords
Comparative Risk of Hospitalized Bleeding of P2Y12 Inhibitors for Secondary Prophylaxis in Acute Coronary Syndrome After Percutaneous Coronary Intervention
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2806
Abstract: In closely monitored randomized controlled trials (RCTs), newer P2Y12 agents (ticagrelor and prasugrel) reduced cardiovascular outcomes compared with clopidogrel following percutaneous coronary intervention (PCI) in acute coronary syndrome. However, these RCTs indicated a higher bleeding… read more here.
Keywords: p2y12; major bleeding; prasugrel; clopidogrel ... See more keywords
Gene polymorphisms of insulin secretion signaling pathway associated with clopidogrel resistance in Han Chinese population.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical laboratory analysis"
DOI: 10.1002/jcla.23970
Abstract: BACKGROUND Due to the loss of responsiveness to insulin, diabetes mellitus (DM) patients develop increased platelet reactivity and reduced response to antiplatelet agents. Nevertheless, the relationship between the single-nucleotide polymorphisms (SNP) of the signal pathway… read more here.
Keywords: gene; clopidogrel resistance; insulin secretion; clopidogrel ... See more keywords
The DNAm levels of CREB5 (cg11301281) were associated with clopidogrel resistance
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24690
Abstract: Clopidogrel resistance (CR) is mostly caused by interindividual variability of the platelet inhibition of clopidogrel, which may induce cardiovascular events. The aim of this research was to evaluate whether DNAm levels of CREB5 (cg01534253) are… read more here.
Keywords: clopidogrel resistance; levels creb5; clopidogrel; dnam levels ... See more keywords
A Comparative Study on Ticagrelor and Clopidogrel in Patients With Acute Coronary Syndrome Treated With Primary Percutaneous Coronary Intervention.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.2239
Abstract: To compare the efficacy and safety of ticagrelor and clopidogrel in patients with acute coronary syndrome (ACS) treated with primary percutaneous coronary intervention (PPCI). 3,528 consecutive patients with ACS treated with PPCI were divided into… read more here.
Keywords: ticagrelor; ticagrelor clopidogrel; clopidogrel patients; clopidogrel ... See more keywords
Analysis of the CYP2C19 genotype associated with bleeding in Serbian STEMI patients who have undergone primary PCI and treatment with clopidogrel
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-017-2401-5
Abstract: PurposeBleeding is one of the possible adverse events during clopidogrel therapy. The CYP2C19 gene is the most significant genetic factor which influences response to clopidogrel treatment. We aimed to examine the contribution of the CYP2C19… read more here.
Keywords: cyp2c19; clopidogrel; rs11568732; rs11568732 variant ... See more keywords
Dual therapy with clopidogrel and aspirin prevents early neurological deterioration in ischemic stroke patients carrying CYP2C19*2 reduced-function alleles
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-018-2468-7
Abstract: PurposeTo investigate the associations between CYP2C19 genotypes and early neurological deterioration (END), and to carry out a stratified analysis of the effectiveness of clopidogrel alone and dual antiplatelet therapy with clopidogrel and aspirin for prevention… read more here.
Keywords: reduced function; clopidogrel; end; therapy ... See more keywords