Gene polymorphisms of insulin secretion signaling pathway associated with clopidogrel resistance in Han Chinese population.
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DOI: 10.1002/jcla.23970
Abstract: BACKGROUND Due to the loss of responsiveness to insulin, diabetes mellitus (DM) patients develop increased platelet reactivity and reduced response to antiplatelet agents. Nevertheless, the relationship between the single-nucleotide polymorphisms (SNP) of the signal pathway… read more here.
Keywords: gene; clopidogrel resistance; insulin secretion; clopidogrel ... See more keywords
The DNAm levels of CREB5 (cg11301281) were associated with clopidogrel resistance
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24690
Abstract: Clopidogrel resistance (CR) is mostly caused by interindividual variability of the platelet inhibition of clopidogrel, which may induce cardiovascular events. The aim of this research was to evaluate whether DNAm levels of CREB5 (cg01534253) are… read more here.
Keywords: clopidogrel resistance; levels creb5; clopidogrel; dnam levels ... See more keywords
Polymorphisms in the GCK gene increase the risk of clopidogrel resistance in stable coronary artery disease (SCAD) patients.
Sign Up to like & getrecommendations! Published in 2021 at "Hematology"
DOI: 10.1080/16078454.2021.1945789
Abstract: BACKGROUND Diabetes mellitus is a major factor in clopidogrel resistance (CR), and the glucokinase (GCK) gene plays a pivotal role in glucose homeostasis. This study investigated the contribution of GCK polymorphisms to CR risk. METHODS… read more here.
Keywords: scad patients; risk; clopidogrel resistance; polymorphisms gck ... See more keywords
Overcoming Clopidogrel Resistance: Three Promising Novel Antiplatelet Drugs Developed in China
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DOI: 10.1097/fjc.0000000000000529
Abstract: Abstract:Clopidogrel is one of the most frequently prescribed drugs worldwide; however, the presence of clopidogrel resistance and high susceptibility to genetic variations and drug interactions are facilitating the development of other antiplatelet drugs. To overcome… read more here.
Keywords: developed china; clopidogrel resistance; antiplatelet drugs; clopidogrel ... See more keywords
Failure of platelet function analyser 200 to demonstrate clinical clopidogrel resistance in a patient undergoing intracranial vascular stenting
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DOI: 10.1136/bcr-2019-233947
Abstract: A patient undergoes intracranial stent insertion for stent-assisted coiling of a basilar tip aneurysm and left middle cerebral artery aneurysm. A flow diverting stent is also placed across an anterior communicating artery aneurysm. Prior to… read more here.
Keywords: clopidogrel resistance; platelet function; platelet; patient ... See more keywords
Correlation P2Y12 Genetic Polymorphism As Risk Factor of Clopidogrel Resistance in Indonesian Stroke Patients
Sign Up to like & getrecommendations! Published in 2023 at "Vascular Health and Risk Management"
DOI: 10.2147/vhrm.s386107
Abstract: Background Stroke is one of the highest causes of disability and mortality in several countries worldwide. Secondary prevention is important in the management of stroke. Clopidogrel is widely used in Asia as secondary prevention for… read more here.
Keywords: polymorphism; clopidogrel resistance; resistance; correlation ... See more keywords
The correlation between platelet responsiveness to clopidogrel and CYP2C19 polymorphism in patients with peripheral vascular disease.
Sign Up to like & getrecommendations! Published in 2021 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202110_26885
Abstract: OBJECTIVE Several patients undergoing endovascular intervention and bypass surgery present with high platelet reactivity following clopidogrel treatment. We aimed to determine the frequency of the genetic polymorphism of CYP2C19*2 and the contribution of this polymorphism… read more here.
Keywords: clopidogrel; clopidogrel resistance; cyp2c19; platelet ... See more keywords
The role of clopidogrel resistance-related genetic and epigenetic factors in major adverse cardiovascular events among patients with acute coronary syndrome after percutaneous coronary intervention
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.1027892
Abstract: Despite patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) and receiving clopidogrel therapy, some patients still experience major adverse cardiovascular events (MACEs). Clopidogrel resistance, which may be regulated by genetic and epigenetic… read more here.
Keywords: cyp2c19; acute coronary; clopidogrel resistance; resistance ... See more keywords
CYP2C19 polymorphisms and lipoproteins associated with clopidogrel resistance in children with Kawasaki disease in China: A prospective study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.925518
Abstract: Background CYP2C19 genetic variation and clinical factors have been proved to be related with clopidogrel resistance (CR) in adults, while the presence of CR in children with Kawasaki disease (KD) was seldom reported. Our objective… read more here.
Keywords: density lipoprotein; cyp2c19; clopidogrel resistance; study ... See more keywords
Clopidogrel Resistance Is Associated With DNA Methylation of Genes From Whole Blood of Humans
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.583215
Abstract: Antiplatelet therapy has become a cornerstone in the treatment of coronary heart disease (CHD). However, due to high-residual-platelet-reactivity, clopidogrel resistance (CR) is a common phenomenon, and it is rarely known about the relationship between CR… read more here.
Keywords: methylation; clopidogrel resistance; differentially methylated; blood ... See more keywords
Ilaprazole and Clopidogrel Resistance in Acute Stroke Patients
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DOI: 10.3390/biomedicines10061366
Abstract: Clopidogrel, an antiplatelet agent used for secondary prevention of cerebrovascular diseases, is often taken with proton pump inhibitors (PPIs). Generally, the combined use of clopidogrel and PPIs causes adverse drug–drug interactions. VerifyNow is a quick… read more here.
Keywords: ilaprazole clopidogrel; clopidogrel resistance; clopidogrel; resistance acute ... See more keywords