Greater neurodegeneration and behavioral deficits after single closed head traumatic brain injury in adolescent versus adult male mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24535
Abstract: Traumatic brain injury (TBI) is a major public health concern affecting 2.8 million people per year in the United States, of whom about 1 million are children under 19 years old. Animal models of TBI… read more here.
Keywords: traumatic brain; closed head; male mice; mice ... See more keywords
Minocycline plus N-acetylcysteine protect oligodendrocytes when first dosed 12 hours after closed head injury in mice
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.06.010
Abstract: The mouse closed head injury (CHI) model of traumatic brain injury (TBI) produces widespread demyelination. Myelin content is restored by minocycline (MINO) plus n-acetylcysteine (NAC) or MINO alone when first dosed at 12 h after CHI.… read more here.
Keywords: head injury; closed head; mino plus; mino ... See more keywords
A Clinically Relevant Closed-Head Model of Single and Repeat Concussive Injury in the Adult Rat Using a Controlled Cortical Impact Device.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neurotrauma"
DOI: 10.1089/neu.2016.4517
Abstract: Abstract Repeat concussions (RC) can result in significant long-term neurological consequences and increased risk for neurodegenerative disease compared with single concussion (SC). Mechanisms underlying this difference are poorly understood and best elucidated using an animal… read more here.
Keywords: adult; adult rat; closed head; repeat ... See more keywords
Glial immune-related pathways mediate effects of closed head traumatic brain injury on behavior and lethality in Drosophila
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001456
Abstract: In traumatic brain injury (TBI), the initial injury phase is followed by a secondary phase that contributes to neurodegeneration, yet the mechanisms leading to neuropathology in vivo remain to be elucidated. To address this question,… read more here.
Keywords: brain injury; injury; lethality; traumatic brain ... See more keywords
Sustained Hippocampal Synaptic Pathophysiology Following Single and Repeated Closed-Head Concussive Impacts
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.652721
Abstract: Traumatic brain injury (TBI), and related diseases such as chronic traumatic encephalopathy (CTE) and Alzheimer’s (AD), are of increasing concern in part due to enhanced awareness of their long-term neurological effects on memory and behavior.… read more here.
Keywords: single repeated; closed head; histopathology; concussive impacts ... See more keywords
Regional variances depict a unique glial-specific inflammatory response following closed-head injury
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2023.1076851
Abstract: Mild traumatic brain injuries (mTBI) constitute a significant health concern with clinical symptoms ranging from headaches to cognitive deficits. Despite the myriad of symptoms commonly reported following this injury, there is still a lack of… read more here.
Keywords: specific inflammatory; closed head; inflammatory response; glial specific ... See more keywords
Translationally Relevant Magnetic Resonance Imaging Markers in a Ferret Model of Closed Head Injury
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.779533
Abstract: Pre-clinical models of traumatic brain injury (TBI) have been the primary experimental tool for understanding the potential mechanisms and cellular alterations that follow brain injury, but the human relevance and translational value of these models… read more here.
Keywords: pre clinical; injury; tbi; closed head ... See more keywords
Posttraumatic Parinaud's syndrome as a contrecoup injury in a case of closed head trauma.
Sign Up to like & getrecommendations! Published in 2022 at "Folia medica"
DOI: 10.3897/folmed.64.e59564
Abstract: The purpose of the study was to present a rare case of post-traumatic Parinaud's syndrome with a history of closed head injury. The clinical characteristics, examination, and management are presented in a 12-year-old boy who… read more here.
Keywords: closed head; parinaud syndrome; case;