Lactone Stabilization is Not a Necessary Feature for Antibody Conjugates of Camptothecins.
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DOI: 10.1021/acs.molpharmaceut.8b00477
Abstract: Camptothecins exist in a pH-dependent equilibrium between the active, closed lactone and the inactive open-carboxylate forms. Several previous reports underscore the need for lactone stabilization in generating improved camptothecins, and indeed, such designs have been… read more here.
Keywords: lactone; closed lactone; stabilization necessary; drug ... See more keywords