Altered closed state inactivation gating in Kv4.2 channels results in developmental and epileptic encephalopathies in human patients
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24396
Abstract: Kv4.2 subunits, encoded by KCND2, serve as the pore‐forming components of voltage‐gated, inactivating ISA K+ channels expressed in the brain. ISA channels inactivate without opening in response to subthreshold excitatory input, temporarily increasing neuronal excitability,… read more here.
Keywords: isa channels; state inactivation; developmental epileptic; inactivation ... See more keywords
Atomistic Study of Intramolecular Interactions in the Closed-State Channelrhodopsin Chimera, C1C2.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.01.023
Abstract: Channelrhodopsins (ChR1 and ChR2) are light-activated ion channels that enable photomobility of microalgae from the genus Chlamydomonas. Despite common use of ChR2 in optogenetics for selective control and monitoring of individual neurons in living tissue,… read more here.
Keywords: chimera c1c2; closed state; c1c2; structure ... See more keywords