Insight into the transition between the open and closed conformations of Thermus thermophilus carboxypeptidase.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.167
Abstract: Carboxypeptidase cleaves the C-terminal amino acid residue from proteins and peptides. Here, we report the functional and structural characterizations of carboxypeptidase belonging to the M32 family from the thermophilic bacterium Thermus thermophilus HB8 (TthCP). TthCP… read more here.
Keywords: open closed; carboxypeptidase; thermus thermophilus; closed states ... See more keywords
Regulation by metal ions and the ADMIDAS of integrin α5β1 conformational states and intrinsic affinities.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e21-11-0536
Abstract: Activation of integrins by Mn2+ is a benchmark in the integrin field, but how it works and whether it reproduces physiologic activation is unknown. We show that Mn2+ and high Mg2+ concentrations compete with Ca2+… read more here.
Keywords: affinity open; metal ions; affinity; intrinsic affinities ... See more keywords