MCC950 closes the active conformation of NLRP3 to an inactive state
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DOI: 10.1038/s41589-019-0278-6
Abstract: NLRP3 (NOD-like receptor pyrin domain-containing protein 3) is an innate immune sensor that contributes to the development of different diseases, including monogenic autoinflammatory syndromes, gout, atherosclerosis, and Alzheimer’s disease. The molecule sulfonylurea MCC950 is a… read more here.
Keywords: mcc950; closes active; conformation; active conformation ... See more keywords