Synthesis of N-Substituted Indoles via Aqueous Ring-Closing Metathesis
Sign Up to like & getrecommendations! Published in 2020 at "Catalysis Letters"
DOI: 10.1007/s10562-020-03271-3
Abstract: Abstract We report herein the synthesis of N -substituted indoles resulting from the ring-closing metathesis of indole precursors bearing N -terminal alkenes. The aqueous metathesis of the indole precursors gave good yields of N -substituted… read more here.
Keywords: metathesis; synthesis substituted; closing metathesis; substituted indoles ... See more keywords
Reaction Mechanism of Ring-Closing Metathesis with a Cationic Molybdenum Imido Alkylidene N-Heterocyclic Carbene Catalyst
Sign Up to like & getrecommendations! Published in 2020 at "Organometallics"
DOI: 10.1021/acs.organomet.0c00311
Abstract: DFT calculations were carried out to explore all relevant pathways for the ring-closing metathesis (RCM) reaction of a cationic molybdenum imido alkylidene N-heterocyclic carbene (NHC) catalyst wit... read more here.
Keywords: imido alkylidene; cationic molybdenum; alkylidene heterocyclic; molybdenum imido ... See more keywords
E-Selective Ring-Closing Metathesis in α-Helical Stapled Peptides Using Carbocyclic α,α-Disubstituted α-Amino Acids.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04256
Abstract: We present an E-selective ring-closing metathesis reaction in α-helical stapled peptides at positions i and i + 4. The use of two chiral carbocyclic α,α-disubstituted α-amino acids, (1S,3S)-Ac5c3OAll and (1R,3S)-Ac5c3OAll, provides a high E-selectivity of… read more here.
Keywords: selective ring; ring closing; helical stapled; amino acids ... See more keywords
Enantioselective Synthesis of cis- and trans-Cycloheptyl β-Fluoro Amines by Sequential aza-Henry Addition/Ring-Closing Metathesis.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.2c04285
Abstract: The synthesis of 7-membered carbocyclic β-fluoroamines is accomplished by a combination of the enantioselective aza-Henry reaction of aliphatic N-Boc imines and ring-closing metathesis. Use of reductive denitration gives both diastereomers of the β-fluoro amine carbocycle,… read more here.
Keywords: closing metathesis; aza henry; ring closing; synthesis ... See more keywords
Ring closing metathesis of unprotected peptides.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc04100d
Abstract: An efficient and expedient route to the synthesis of dicarba peptides from protecting group-free sequences is reported using Ru-alkylidene catalysed olefin metathesis. A range of cyclic peptides was prepared from linear peptides containing two Z-crotyl… read more here.
Keywords: unprotected peptides; metathesis unprotected; closing metathesis; metathesis ... See more keywords
Synthesis of 8′,11′-dihydrospiro[cyclohexane-1,2′-oxepino[2,3-h] chromen]-4′(3′H)-ones with ring closing metathesis as a key step
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra07920j
Abstract: A series of novel hybrid molecular entities incorporating various spiro chromanone scaffolds onto the benzannulated oxepine core moiety were synthesised using allylation, Claisen rearrangement, Kabbe condensation and Ring Closing Metathesis (RCM) as a key step.… read more here.
Keywords: key step; closing metathesis; synthesis; ring closing ... See more keywords
Microwave Enhancement on Ring-closing Metathesis of Macrocyclic Bisazole
Sign Up to like & getrecommendations! Published in 2017 at "Chemistry Letters"
DOI: 10.1246/cl.160982
Abstract: Microwave irradiation was applied to a sterically demanding ring-closing metathesis catalyzed by a second-generation Grubbs catalyst. Under strict temperature control, reaction acceleration by microwave irradiation was observed. The observed acceleration effect was estimated to be… read more here.
Keywords: enhancement ring; ring closing; closing metathesis; microwave enhancement ... See more keywords
Template Synthesis for Disilamacrocycles via Ring-closing Metathesis
Sign Up to like & getrecommendations! Published in 2021 at "Chemistry Letters"
DOI: 10.1246/cl.210234
Abstract: A facile and novel template synthesis of flexible disilamacrocyclic compounds via a ring-closing metathesis coupling was achieved. The structures of the macrocycles were determined by X-ray crystal... read more here.
Keywords: ring closing; template synthesis; closing metathesis; via ring ... See more keywords
Synthesis of Dihydropyrano[3,2-c]pyrazoles via Double Bond Migration and Ring-Closing Metathesis
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24020296
Abstract: Three types of pyrazole-fused heterobicycles, i.e., 1,5-, 1,7-, and 2,5-dihydropyrano[3,2-c]pyrazoles, were synthesized from 4-allyloxy-1H-pyrazoles. A sequence of the Claisen rearrangement of 4-allyloxy-1H-pyrazoles, ruthenium-hydride-catalyzed double bond migration, O-allylation, and ring-closing metathesis was employed in this study. read more here.
Keywords: dihydropyrano pyrazoles; closing metathesis; bond migration; double bond ... See more keywords
Design and synthesis of C 3-symmetric molecules bearing propellane moieties via cyclotrimerization and a ring-closing metathesis sequence
Sign Up to like & getrecommendations! Published in 2018 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.14.230
Abstract: We have developed an efficient synthetic strategy to assemble C 3-symmetric molecules containing propellane moieties as end groups and a benzene ring as a central core. The synthesis of these C 3-symmetric molecules involves simple… read more here.
Keywords: synthesis symmetric; cyclotrimerization ring; symmetric molecules; propellane moieties ... See more keywords
Design, synthesis and photophysical properties of novel star-shaped truxene-based heterocycles utilizing ring-closing metathesis, Clauson–Kaas, Van Leusen and Ullmann-type reactions as key tools
Sign Up to like & getrecommendations! Published in 2021 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.17.96
Abstract: Design, synthesis and properties of polycyclic aromatic hydrocarbons (PAHs) has historically attracted a considerable interdisciplinary interest from both fundamental as well as applied viewpoint on account of their wonderful optoelectronic properties. The scientific interest in… read more here.
Keywords: design synthesis; star shaped; truxene; closing metathesis ... See more keywords