Two Feet on the Membrane: Uptake of Clostridial Neurotoxins.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in microbiology and immunology"
DOI: 10.1007/82_2016_48
Abstract: The extraordinary potency of botulinum neurotoxins (BoNT) and tetanus neurotoxin (TeNT) is mediated by their high neurospecificity, targeting peripheral cholinergic motoneurons leading to flaccid and spastic paralysis, respectively, and successive respiratory failure. Complex polysialo gangliosides… read more here.
Keywords: two feet; feet membrane; ganglioside binding; membrane uptake ... See more keywords
A neurotoxin that specifically targets Anopheles mosquitoes
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10732-w
Abstract: Clostridial neurotoxins, including tetanus and botulinum neurotoxins, generally target vertebrates. We show here that this family of toxins has a much broader host spectrum, by identifying PMP1, a clostridial-like neurotoxin that selectively targets anopheline mosquitoes.… read more here.
Keywords: targets anopheles; bifermentans strains; anopheles mosquitoes; specifically targets ... See more keywords