Association Between Environmental Factors and Toxigenic Clostridioides difficile Carriage at Hospital Admission
Sign Up to like & getrecommendations! Published in 2020 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2019.19132
Abstract: Key Points Question Is an individual’s location of residence associated with asymptomatic carriage of toxigenic Clostridiodes difficile? Findings In this cohort study of 3043 adult participants admitted to the hospital, patients who lived closer to… read more here.
Keywords: hospital admission; environmental factors; association environmental; clostridioides difficile ... See more keywords
Incidence and Outcomes Associated With Clostridioides difficile Infection in Solid Organ Transplant Recipients
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.41089
Abstract: Key Points Question What are the incidence and outcomes associated with posttransplant Clostridioides difficile infection (CDI) in people who have undergone solid organ transplant? Findings In this cohort study including 10 724 patients, posttransplant CDI was… read more here.
Keywords: outcomes associated; organ transplant; clostridioides difficile; incidence outcomes ... See more keywords
Assessment of Quality of Life Among Patients With Recurrent Clostridioides difficile Infection Treated with Investigational Oral Microbiome Therapeutic SER-109
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.53570
Abstract: This secondary analysis of a randomized clinical trial examines the association of SER-109 with health-related quality of life in 182 patients with recurrent Clostridioides difficile infection in the US and Canada. read more here.
Keywords: recurrent clostridioides; clostridioides difficile; difficile infection; patients recurrent ... See more keywords
Safety and Tolerability of SER-109 as an Investigational Microbiome Therapeutic in Adults With Recurrent Clostridioides difficile Infection
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.55758
Abstract: This phase 3, open-label, single-arm trial assesses the safety of SER-109 and the rate of recurrent Clostridioides difficile infection after administration of SER-109 following symptom resolution after antibiotic treatment among adults. read more here.
Keywords: recurrent clostridioides; safety; clostridioides difficile; difficile infection ... See more keywords
Oral Vancomycin for Prevention of Recurrent Clostridioides difficile Infection
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2025.17834
Abstract: This randomized clinical trial examines whether prophylactic oral vancomycin vs placebo reduces recurrent Clostridioides difficile infection in adults receiving antibiotics for another indication. read more here.
Keywords: clostridioides difficile; recurrent clostridioides; oral vancomycin; difficile infection ... See more keywords
Development of Peptide Glucosyltransferase Inhibitors With Comprehensive Coverage Across Clostridioides difficile Toxin B Sub-Types.
Sign Up to like & getrecommendations! Published in 2025 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.70102
Abstract: Clostridioides difficile infection presents an escalating clinical challenge due to the proliferation of hypervirulent and antibiotic‐resistant strains. The primary symptoms of disease, namely colitis and diarrhea, are induced by the release of two toxins: TcdA… read more here.
Keywords: clostridioides difficile; development; toxin; development peptide ... See more keywords
Synthesis of Muramyl‐δ‐Lactam in Spore Peptidoglycan of Clostridioides difficile
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202300282
Abstract: Clostridioides difficile is a spore‐forming human pathogen responsible for significant morbidity and mortality. Infections by this pathogen ensue dysbiosis of the intestinal tract, which leads to germination of the spores. The process of spore formation… read more here.
Keywords: clostridioides difficile; muramyl lactam; lactam spore; synthesis muramyl ... See more keywords
Molecular epidemiology and clinical characteristics of Clostridioides difficile infection in patients with inflammatory bowel disease from a teaching hospital
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24773
Abstract: Clostridioides difficile infection (CDI) in patients with inflammatory bowel disease (IBD) is of increasing concern. This study aimed to investigate the molecular epidemiology and antimicrobial susceptibilities of toxigenic C. difficile isolated from IBD patients and… read more here.
Keywords: clostridioides difficile; patients inflammatory; inflammatory bowel; difficile infection ... See more keywords
Higher mortality rates associated with Clostridioides difficile infection in hospitalized children with cystic fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.26214
Abstract: To determine the association of Clostridioides difficile Infection (CDI) with in‐hospital mortality, Length of Stay (LOS), and hospital charges among pediatric Cystic Fibrosis (CF) hospitalizations using a large nationally representative pediatric hospital database. read more here.
Keywords: cystic fibrosis; clostridioides difficile; mortality; difficile infection ... See more keywords
Performance of commercial PCR assays to detect toxigenic Clostridioides difficile in the feces of puppies
Sign Up to like & getrecommendations! Published in 2021 at "Veterinary Medicine and Science"
DOI: 10.1002/vms3.567
Abstract: Abstract Clostridioides difficile is an important enteric pathogen that causes significant morbidity and mortality in humans. With community‐acquired infections on the rise, it is important to identify reservoirs of the pathogen. Companion animals can be… read more here.
Keywords: clostridioides difficile; predictive values; performance commercial; commercial pcr ... See more keywords
Comparison of Anaerobic Culture Methods for Detecting Clostridioides difficile in Bovine Faeces
Sign Up to like & getrecommendations! Published in 2024 at "Veterinary Medicine and Science"
DOI: 10.1002/vms3.70085
Abstract: ABSTRACT Background The study of the epidemiology of Clostridioides difficile in populations is greatly facilitated by the ability to isolate and further characterize individual organisms, which requires effective culture protocols. In cattle, where little is… read more here.
Keywords: epidemiology; culture protocols; culture; bovine faeces ... See more keywords