Mechanisms for Reduced Fibrin Clot Formation on Liquid‐Infused Surfaces
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201360
Abstract: Biomedical devices are prone to blood clot formation (thrombosis), and liquid‐infused surfaces (LIS) are effective in reducing the thrombotic response. However, the mechanisms that underpin this performance, and in particular the role of the lubricant,… read more here.
Keywords: infused surfaces; clot formation; reduced fibrin; liquid infused ... See more keywords
Combination of polycarboxybetaine coating and factor XII inhibitor reduces clot formation while preserving normal tissue coagulation during extracorporeal life support.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.120778
Abstract: Blood contact with high surface area medical devices, such as dialysis and extracorporeal life support (ECLS), induces rapid surface coagulation. Systemic anticoagulation, such as heparin, is thus necessary to slow clot formation, but some patients… read more here.
Keywords: anticoagulation; coagulation; heparin; clot formation ... See more keywords
Fibrin clot formation under diverse clotting conditions: Comparing turbidimetry and thromboelastography.
Sign Up to like & getrecommendations! Published in 2020 at "Thrombosis research"
DOI: 10.1016/j.thromres.2020.01.001
Abstract: Thrombosis is a leading cause of death around the world. Fibrin, the protein primarily responsible for clot formation, is formed via cleaving soluble fibrinogen by thrombin with resulting properties varying under different clot forming conditions.… read more here.
Keywords: clot; fibrinogen; turbidimetry; clot formation ... See more keywords
Nano- and Micropatterned Polycaprolactone Cellulose Composite Surfaces with Tunable Protein Adsorption, Fibrin Clot Formation, and Endothelial Cellular Response
Sign Up to like & getrecommendations! Published in 2019 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.9b00304
Abstract: This work describes the interaction of the human blood plasma proteins albumin, fibrinogen, and γ-globulins with micro- and nanopatterned polymer interfaces. Protein adsorption studies were correlated with the fibrin clotting time of human blood plasma… read more here.
Keywords: adsorption; composite surfaces; protein adsorption; clot formation ... See more keywords
Investigation of thrombin concentration at the time of clot formation in simultaneous thrombin and fibrin generation assays
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-023-47694-5
Abstract: Thrombin generation (TG) and fibrin clot formation represent the central process of blood coagulation. Up to 95% of thrombin is considered to be generated after the clot is formed. However, this was not investigated in… read more here.
Keywords: time; generation; clot; clot formation ... See more keywords
Clot Formation in Cardiopulmonary Bypass Circuit After Application of Factor XI Concentrate.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cardiothoracic and vascular anesthesia"
DOI: 10.1053/j.jvca.2020.02.013
Abstract: Abstract We report a case of clot formation in the cardiopulmonary bypass in a patient with type C hemophilia after receiving FXI concentrate. Caution is warranted when using FXI concentrate in cardiac surgery. read more here.
Keywords: formation cardiopulmonary; clot formation; cardiopulmonary bypass; concentrate ... See more keywords
Long-term differences in clot formation and endothelial function between STEMI patients with occlusion of infarct-related artery and those with spontaneous reperfusion
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.1549
Abstract: Enhanced activation of endogenous fibrinolysis in ST-elevation myocardial infarction (STEMI) patients is the main cause of spontaneous reperfusion of the infarct-related artery (IRA) in the acute period. Whether this enhanced activation remains in the deferred… read more here.
Keywords: mcm min; clot formation; group; spontaneous reperfusion ... See more keywords
Coagulation testing and management in liver disease patients.
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Gastroenterology"
DOI: 10.1097/mog.0000000000000635
Abstract: PURPOSE OF REVIEW The present article aims to provide clinicians with an overview of coagulation testing in individuals with liver disease, to discuss available procoagulants and the rationale for their use, and to provide management… read more here.
Keywords: management; clot formation; coagulation; coagulation testing ... See more keywords
In vitro effects of a kaolin-coated hemostatic dressing on anticoagulated blood
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Trauma and Acute Care Surgery"
DOI: 10.1097/ta.0000000000001999
Abstract: BACKGROUND The use of kaolin-coated dressings has become common and have efficacy in normal patients, but their increased use will inevitably include use on bleeding patients taking anticoagulants. We hypothesize that kaolin coating material (KCM)… read more here.
Keywords: clot; kaolin coated; kcm; clot formation ... See more keywords
Effects of Post-Translational Modifications of Fibrinogen on Clot Formation, Clot Structure, and Fibrinolysis
Sign Up to like & getrecommendations! Published in 2020 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.119.313626
Abstract: Supplemental Digital Content is available in the text. Objective: Post-translational modifications of fibrinogen influence the occurrence and progression of thrombotic diseases. In this systematic review, we assessed the current literature on post-translational modifications of fibrinogen… read more here.
Keywords: modifications fibrinogen; translational modifications; clot formation; post translational ... See more keywords
The ACE2 decoy receptor can overcome immune escape by rapid mutating SARS-CoV-2 variants and reduce cytokine induction and clot formation
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biomedical Science"
DOI: 10.1186/s12929-025-01156-4
Abstract: The COVID-19 pandemic continues to affect the world in 2025. The rapid mutation of SARS-CoV-2 results in breakthrough infections and diminishes the efficacy of vaccines and anti-viral drugs. The severity of the disease varies across… read more here.
Keywords: sars cov; mutating sars; spike; clot formation ... See more keywords