Targeted therapy in patients with PIK3CA-related overgrowth syndrome
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DOI: 10.1038/s41586-018-0217-9
Abstract: CLOVES syndrome (congenital lipomatous overgrowth, vascular malformations, epidermal naevi, scoliosis/skeletal and spinal syndrome) is a genetic disorder that results from somatic, mosaic gain-of-function mutations of the PIK3CA gene, and belongs to the spectrum of PIK3CA-related… read more here.
Keywords: cloves syndrome; pros cloves; related overgrowth; pik3ca related ... See more keywords
Use of intercostal nerve block for chest wall pain in a patient with CLOVES syndrome.
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DOI: 10.2217/pmt-2021-0120
Abstract: Congenital lipomatous overgrowth, vascular malformations, epidermal nevi and scoliosis/skeletal/spinal anomalies (CLOVES) syndrome is an extremely rare overgrowth syndrome characterized by complex vascular malformations. Management requires an interdisciplinary approach including debulking operations for tissue overgrowth, embolization therapy for… read more here.
Keywords: vascular malformations; cloves syndrome; intercostal nerve; pain ... See more keywords
CLOVES syndrome: Treatment with oral Rapamycin. Report of two cases.
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DOI: 10.32641/rchped.v90i6.1025
Abstract: INTRODUCTION CLOVES syndrome is characterized by lipomatous overgrowth associated with vascular malforma tions, representing a diagnostic and a therapeutic challenge. Rapamycin, an mTOR inhibitor, has proved to be a good therapeutic option in some vascular… read more here.
Keywords: report two; cloves syndrome; treatment; oral rapamycin ... See more keywords