Associations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2022.4234
Abstract: Importance Predictors consistently associated with psychosis liability and course of illness in schizophrenia (SCZ) spectrum disorders (SSD), including the need for clozapine treatment, are lacking. Longitudinally ascertained medication use may empower studies examining associations between… read more here.
Keywords: prs scz; polygenic risk; ssd taking; individuals ssd ... See more keywords
Clozapine prescribing practice and trends in Qatar: First national observational study
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2617
Abstract: Clozapine is the gold standard in the management of treatment‐resistant schizophrenia. Despite its clinically proven efficacy clozapine utilization is variable globally and published evidence is suggestive of its underutilization. Research from the Arab region on… read more here.
Keywords: prescribing practice; observational study; clozapine;
Naringin treatment improved main clozapine-induced adverse effects in rats; emphasis on weight gain, metabolic abnormalities, and agranulocytosis.
Sign Up to like & getrecommendations! Published in 2021 at "Drug development research"
DOI: 10.1002/ddr.21800
Abstract: Schizophrenia is one of the major neuropsychiatric disorders affecting people worldwide. Unfortunately, currently available antipsychotic medications possess several side effects. Among them, clozapine is one of the atypical antipsychotics prescribed in schizophrenia wing to its… read more here.
Keywords: clozapine; treatment; adverse effects; naringin treatment ... See more keywords
Protective effects of salvianolic acid A on clozapine‐induced cardiotoxicity in zebrafish
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4368
Abstract: The clinical use of clozapine (CLZ), an atypical antipsychotic drug, was affected by side effects, such as cardiotoxicity. We selected normally developing zebrafish embryos to explore the antagonism of salvianolic acid A (SAA) against clozapine‐induced… read more here.
Keywords: induced cardiotoxicity; cardiotoxicity; salvianolic acid; clozapine induced ... See more keywords
Effects of Chronic Treatment of Haloperidol and Clozapine on Levels of G-Protein Subunits in Rat Striatum
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Neuroscience"
DOI: 10.1007/bf03380139
Abstract: Chronic administration of typical neuroleptic drugs, such as haloperidol, causes the supersensitivity of brain dopamine D2 receptor in striatum and limbic regions, while the atypical neuroleptic clozapine does not. In order to understand the mechanism… read more here.
Keywords: treatment haloperidol; clozapine; chronic treatment; treatment ... See more keywords
Food craving and consumption evolution in patients starting treatment with clozapine
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05291-3
Abstract: BackgroundAntipsychotic-induced weight gain has been especially related to clozapine and olanzapine. Underlying mechanisms in relation to food preferences with an increased food craving and consumption of specific nutrients have not been extensively studied in patients… read more here.
Keywords: patients starting; clozapine; treatment; food craving ... See more keywords
The effect of sublingual atropine sulfate on clozapine-induced hypersalivation: a multicentre, randomised placebo-controlled trial.
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05627-4
Abstract: BACKGROUND Hypersalivation and drooling are commonly reported in clozapine-treated patients. Current management strategies have been evaluated using subjective measures. Many case reports describe the successful use of atropine in the treatment of the condition. AIMS… read more here.
Keywords: sublingual atropine; clozapine; hypersalivation; effect ... See more keywords
Case Report: Successful Use of the Combination of Electroconvulsive Therapy and Clozapine in Treating Treatment-Resistant Schizophrenia and Catatonia in an Adult with Intellectual Disability
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Autism and Developmental Disorders"
DOI: 10.1007/s10803-018-3589-7
Abstract: There is paucity of empirical data regarding the use of either clozapine or electroconvulsive therapy (ECT) in the acute phase and maintenance treatment of schizophrenia in adults with intellectual disability. Herein we report the successful… read more here.
Keywords: combination; schizophrenia; treatment resistant; clozapine ... See more keywords
Adjunctive Minocycline in Clozapine-Treated Patients with Schizophrenia: Analyzing the Effects of Minocycline on Clozapine Plasma Levels
Sign Up to like & getrecommendations! Published in 2017 at "Psychiatric Quarterly"
DOI: 10.1007/s11126-017-9515-x
Abstract: Clozapine is the sole antipsychotic agent effective for the treatment of refractory schizophrenia. Sixty percent of clozapine-treated patients, however, fail to adequately respond. Minocycline, a tetracycline antibiotic, possesses antiinflammatory and neuroprotective properties that may play… read more here.
Keywords: plasma levels; minocycline clozapine; clozapine plasma; clozapine ... See more keywords
Clozapine Induced Developmental and Cardiac Toxicity on Zebrafish Embryos by Elevating Oxidative Stress.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular toxicology"
DOI: 10.1007/s12012-021-09632-7
Abstract: Clozapine is one of the antipsychotic drugs for treating schizophrenia, but its cardiotoxicity was the primary obstacle for its clinical use, due to the unknown mechanism of clozapine-induced cardiotoxicity. In this study, we studied the… read more here.
Keywords: clozapine; clozapine induced; zebrafish embryos; cardiotoxicity ... See more keywords
Air-assisted surfactant-enhanced emulsification liquid–liquid microextraction based on the solidification of floating organic droplets followed by high-performance liquid chromatography with ultraviolet detection for the determination of Clozapine in biological samples
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-019-01695-2
Abstract: In this study, a simple, efficient, and inexpensive microextraction method based on air-assisted surfactant-enhanced emulsification liquid–liquid microextraction based on the solidification of floating organic droplets (ASEME-SFO) was used for pre-concentration and determination of Clozapine in… read more here.
Keywords: liquid; clozapine; determination; surfactant ... See more keywords