Protective effects of salvianolic acid A on clozapine‐induced cardiotoxicity in zebrafish
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DOI: 10.1002/jat.4368
Abstract: The clinical use of clozapine (CLZ), an atypical antipsychotic drug, was affected by side effects, such as cardiotoxicity. We selected normally developing zebrafish embryos to explore the antagonism of salvianolic acid A (SAA) against clozapine‐induced… read more here.
Keywords: induced cardiotoxicity; cardiotoxicity; salvianolic acid; clozapine induced ... See more keywords
Clozapine Induced Developmental and Cardiac Toxicity on Zebrafish Embryos by Elevating Oxidative Stress.
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DOI: 10.1007/s12012-021-09632-7
Abstract: Clozapine is one of the antipsychotic drugs for treating schizophrenia, but its cardiotoxicity was the primary obstacle for its clinical use, due to the unknown mechanism of clozapine-induced cardiotoxicity. In this study, we studied the… read more here.
Keywords: clozapine; clozapine induced; zebrafish embryos; cardiotoxicity ... See more keywords
Clozapine-Induced Gastrointestinal Hypomotility: A 22-Year Bi-National Pharmacovigilance Study of Serious or Fatal ‘Slow Gut’ Reactions, and Comparison with International Drug Safety Advice
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DOI: 10.1007/s40263-017-0448-6
Abstract: IntroductionClozapine is the preferred antipsychotic for treatment-resistant schizophrenia, but has significant adverse effects, including gastrointestinal hypomotility or ‘slow gut’, which may result in severe constipation, ileus, bowel obstruction, and even death. These gastrointestinal effects remain… read more here.
Keywords: clozapine; clozapine induced; slow gut; study ... See more keywords
Risk factors for clozapine-induced central nervous system abnormalities in Japanese patients with treatment-resistant schizophrenia.
Sign Up to like & getrecommendations! Published in 2021 at "Asian journal of psychiatry"
DOI: 10.1016/j.ajp.2021.102652
Abstract: The purpose of this study was to assess the risk factors for clozapine-induced central nervous system (CNS) abnormalities (i.e., electroencephalogram [EEG] abnormalities, myoclonus, and seizures). We retrospectively analyzed data from 106 patients with schizophrenia who… read more here.
Keywords: clozapine induced; factors clozapine; treatment; risk factors ... See more keywords
SU93 REPLICATION OF TWO INDEPENDENT LOCI IN HLA-DQB1 AND HLA-B CONTRIBUTING TO THE RISK OF CLOZAPINE-INDUCED AGRANULOCYTOSIS
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.282
Abstract: Background The atypical antipsychotic drug clozapine is the only effective drug for treatment-resistant schizophrenia, but also bears the risk of inducing severe adverse drug responses like neutropenia and agranulocytosis. Agranulocytosis and neutropenia occurs in about… read more here.
Keywords: clozapine; induced agranulocytosis; hla dqb1; clozapine induced ... See more keywords
Mild to moderate clozapine-induced gastrointestinal hypomotility should not require cessation of clozapine.
Sign Up to like & getrecommendations! Published in 2017 at "General hospital psychiatry"
DOI: 10.1016/j.genhosppsych.2017.06.007
Abstract: Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised… read more here.
Keywords: version; clozapine; moderate clozapine; clozapine induced ... See more keywords
Reporting of clozapine-induced gastrointestinal hypomotility and factors associated with fatal outcomes in Canada: A pharmacovigilance database study
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DOI: 10.1016/j.psychres.2020.113048
Abstract: Clozapine-induced gastrointestinal hypomotility (CIGH) is poorly understood and potentially life-threatening. Herein, we present trends of CIGH annual reporting and explore factors associated with a fatal outcome using 25-years of pharmacovigilance data in Canada. Since 1993,… read more here.
Keywords: clozapine; clozapine induced; factors associated; associated fatal ... See more keywords
Sublingual atropine in the treatment of clozapine-induced sialorrhea
Sign Up to like & getrecommendations! Published in 2017 at "Schizophrenia Research"
DOI: 10.1016/j.schres.2016.10.039
Abstract: Article history: Received 23 June 2016 Received in revised form 25 October 2016 Accepted 28 October 2016 Available online xxxx tion of clozapine, the patients were not prescribed any other psychotropic medication though all patients… read more here.
Keywords: sublingual atropine; clozapine; clozapine induced; treatment ... See more keywords
Treatment strategies for clozapine-induced nocturnal enuresis and urinary incontinence: a systematic review
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DOI: 10.1017/s1092852922000050
Abstract: Abstract Background Clozapine is the most effective medication for treatment-refractory schizophrenia but is associated with significant adverse drug reactions, including nocturnal enuresis and urinary incontinence. This side effect can be burdensome and lead to medication… read more here.
Keywords: clozapine induced; urinary incontinence; enuresis urinary; nocturnal enuresis ... See more keywords
Tropicamide ophthalmic solution reduces clozapine-induced sialorrhea: a case report
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DOI: 10.1080/24750573.2017.1347601
Abstract: ABSTRACT Clozapine-induced sialorrhea (CIS) is a common, treatment-limiting, and stigmatizing side effect. All systemic agents that are used for CIS may increase clozapine side effects such as blood pressure changes, constipation, or arrhythmias or may… read more here.
Keywords: cis; clozapine induced; ophthalmic solution; effect ... See more keywords
M200. CLOZAPINE-INDUCED HEPATOTOXICITY: TWO CASE REPORTS
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DOI: 10.1093/schbul/sbaa030.512
Abstract: Abstract Background Liver function tests (LFT) abnormalities secondary to antipsychotics (AP) are common, early, and often mild and transient. Up to 60% of patients on clozapine experience an increase in LFT, at medium-range doses (200–400mg),… read more here.
Keywords: induced hepatotoxicity; clozapine; clozapine induced; case ... See more keywords