Clozapine and Gastrointestinal Hypomotility
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DOI: 10.1007/s40263-017-0481-5
Abstract: Gastrointestinal hypomotility (GIH) is an under-reported but highly prevalent and potentially dangerous side effect of clozapine. In a comprehensive meta-analysis of clozapine-treated patients, the prevalence of GIH was 32%. In general, GIH has consistently been… read more here.
Keywords: clozapine treated; gastrointestinal hypomotility; treatment; gih ... See more keywords
Clozapine-treated patients and myocardial infarction in adults: a pharmacovigilance study in VigiBase interpreted in the context of the literature.
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DOI: 10.1080/14740338.2025.2518234
Abstract: BACKGROUND Clozapine is the best treatment for treatment-resistant schizophrenia (TRS) but is associated with metabolic adverse drug reactions (ADRs). RESEARCH DOSING/METHODS The international pharmacovigilance database (VigiBase) uses the information component (IC) as a disproportionality analysis.… read more here.
Keywords: treated patients; myocardial infarction; clozapine treated; pharmacovigilance ... See more keywords
Neutropenia in Patients With Clozapine-Treated Schizophrenia: An Effect of Clozapine or a Consequence of SARS-CoV-2 Infection? A Systematic Review
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DOI: 10.1097/mjt.0000000000001532
Abstract: Background: Clozapine is the only approved antipsychotic for treatment-resistant schizophrenia. Despite its therapeutic benefits, it is still widely underused, mainly because of its potential to cause agranulocytosis and neutropenia. Prescribing clozapine in COVID-19–positive patients became… read more here.
Keywords: clozapine treated; clozapine treatment; treatment; clozapine ... See more keywords
Association between electroencephalogram changes and plasma clozapine levels in clozapine-treated patients
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DOI: 10.1097/yic.0000000000000255
Abstract: This retrospective observational study was performed to investigate electroencephalogram abnormalities in clozapine-treated patients with refractory schizophrenia or bipolar disorder. The electroencephalogram and plasma clozapine and norclozapine levels in 71 patients were measured on the same… read more here.
Keywords: clozapine; clozapine levels; electroencephalogram abnormalities; clozapine treated ... See more keywords
Low levels of serum vitamin D in clozapine-treated schizophrenia patients are associated with high levels of the proinflammatory cytokine IL-6
Sign Up to like & getrecommendations! Published in 2020 at "International Clinical Psychopharmacology"
DOI: 10.1097/yic.0000000000000303
Abstract: Low levels of vitamin D are prevalent among patients with schizophrenia and have been linked to the risk and outcome of the disorder. Vitamin D has a regulatory effect on the inflammatory system, which is… read more here.
Keywords: serum vitamin; schizophrenia patients; treated schizophrenia; clozapine treated ... See more keywords
A retrospective analysis of cardiovascular outcomes of clozapine treated individuals within Hunter New England
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DOI: 10.1111/imj.16617
Abstract: Clozapine has demonstrated superiority in improving both positive and negative symptoms of treatment‐resistant schizophrenia; however, there are associated treatment‐limiting side effects, including myocarditis, cardiomyopathy and agranulocytosis. read more here.
Keywords: analysis cardiovascular; retrospective analysis; outcomes clozapine; cardiovascular outcomes ... See more keywords