RX-207, a Small Molecule Inhibitor of Protein Interaction with Glycosaminoglycans (SMIGs), Reduces Experimentally Induced Inflammation and Increases Survival Rate in Cecal Ligation and Puncture (CLP)-Induced Sepsis
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DOI: 10.1007/s10753-017-0688-0
Abstract: The fused quinazolinone derivative, RX-207, is chemically and functionally related to small molecule inhibitors of protein binding to glycosaminoglycans (SMIGs). Composed of a planar aromatic amine scaffold, it inhibits protein binding to glycosaminoglycans (GAGs). RX-207… read more here.
Keywords: small molecule; induced sepsis; inflammation; clp induced ... See more keywords
Liver nitrosation and inflammation in septic rats were suppressed by propofol via downregulating TLR4/NF‐&kgr;B‐mediated iNOS and IL‐6 gene expressions
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DOI: 10.1016/j.lfs.2018.01.005
Abstract: Aims: Propofol can be applied as an anesthetic or sedative agent for septic patients. Our previous studies showed that propofol ameliorated inflammation‐ and nitrosative stress‐induced cellular insults. This study further evaluated effects of propofol on… read more here.
Keywords: clp; gene expressions; clp induced; inos gene ... See more keywords
Positive Role of Delta Neutrophil Index (DNI) as a Prodiagnostic Marker in Cecal Ligation and Puncture (CLP)-Induced Sepsis Murine Model
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DOI: 10.3390/medicina58030369
Abstract: Sepsis is an emergent infectious disease and a leading cause of death despite immediate intervention. While Delta neutrophil index (DNI) and myeloperoxidase (MPO) are known as a prodiagnostic marker of sepsis, the preclinical evidence of… read more here.
Keywords: sepsis; clp; marker; clp induced ... See more keywords