The Non-dominant AAA+ Ring in the ClpAP Protease Functions as an Anti-stalling Motor to Accelerate Protein Unfolding and Translocation.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.110
Abstract: ATP-powered unfoldases containing D1 and D2 AAA+ rings play important roles in protein homeostasis, but uncertainty about the function of each ring remains. Here we use single-molecule optical tweezers to assay mechanical unfolding and translocation… read more here.
Keywords: protein; clpap protease; translocation; motor ... See more keywords
ClpAP protease is a universal factor that activates the parDE toxin-antitoxin system from a broad host range RK2 plasmid
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DOI: 10.1038/s41598-018-33726-y
Abstract: The activity of type II toxin-antitoxin systems (TA), which are responsible for many important features of bacterial cells, is based on the differences between toxin and antitoxin stabilities. The antitoxin lability results from bacterial protease… read more here.
Keywords: toxin antitoxin; toxin; antitoxin; clpap protease ... See more keywords