Factors Underlying Asymmetric Pore Dynamics of Disaggregase and Microtubule Severing AAA+ Machines.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.05.027
Abstract: Disaggregation and microtubule-severing nanomachines from the AAA+ (ATPases associated with various cellular activities) superfamily assemble into ring-shaped hexamers that enable protein remodeling by coupling large-scale conformational changes with application of mechanical forces within a central… read more here.
Keywords: severing proteins; clpb; asymmetric pore; microtubule severing ... See more keywords
Escherichia coli DnaK Allosterically Modulates ClpB between High- and Low-Peptide Affinity States.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00045
Abstract: ClpB and DnaKJE provide protection to Escherichia coli cells during extreme environmental stress. Together, this co-chaperone system can resolve protein aggregates, restoring misfolded proteins to their native form and function in solubilizing damaged proteins for… read more here.
Keywords: escherichia coli; clpb; peptide affinity; low peptide ... See more keywords
Tunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09474-6
Abstract: Large protein machines are tightly regulated through allosteric communication channels. Here we demonstrate the involvement of ultrafast conformational dynamics in allosteric regulation of ClpB, a hexameric AAA+ machine that rescues aggregated proteins. Each subunit of ClpB… read more here.
Keywords: machine; tunable microsecond; clpb; dynamics allosteric ... See more keywords
ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1810648115
Abstract: Significance The Mycobacterium tuberculosis (Mtb) ClpB is a ring-shaped, ATP-driven disaggregase. The ability to rescue aggregated proteins is crucial for Mtb to grow and persist in the host. Despite extensive studies in the past two… read more here.
Keywords: mtb clpb; peptide translocation; clpb; tuberculosis ... See more keywords
Nonredundant functions of Mycobacterium tuberculosis chaperones promote survival under stress
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Microbiology"
DOI: 10.1111/mmi.14615
Abstract: Bacterial chaperones ClpB and DnaK, homologs of the respective eukaryotic heat shock proteins Hsp104 and Hsp70, are essential in the reactivation of toxic protein aggregates that occur during translation or periods of stress. In the… read more here.
Keywords: stress; clpb; stress response; mycobacterium tuberculosis ... See more keywords
Characterization and functional analysis of clpB gene from Acidovorax avenae subsp. avenae RS‐1
Sign Up to like & getrecommendations! Published in 2017 at "Plant Pathology"
DOI: 10.1111/ppa.12685
Abstract: The type VI secretion system (T6SS) has been reported to be highly associated with various cellular activities in strain RS-1 of Acidovorax avenae subsp. avenae (Aaa), the pathogen of bacterial brown stripe of rice. However,… read more here.
Keywords: clpb; clpb gene; avenae subsp; acidovorax avenae ... See more keywords