Toxic Activation of an AAA+ Protease by the Antibacterial Drug Cyclomarin A.
Sign Up to like & getrecommendations! Published in 2019 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2019.05.008
Abstract: ATP-driven bacterial AAA+ proteases have been recognized as drug targets. They possess an AAA+ protein (e.g., ClpC), which threads substrate proteins into an associated peptidase (e.g., ClpP). ATPase activity and substrate selection of AAA+ proteins… read more here.
Keywords: cyma; aaa protease; cyclomarin; clpc ... See more keywords
Structure of the central Staphylococcus aureus AAA+ protease MecA/ClpC/ClpP
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-08908-w
Abstract: Bacterial AAA+ proteases are composed of a AAA+ partner (e.g. ClpC) and an associated peptidase (e.g. ClpP). They represent ATP-fuelled and self-compartmentalized proteolytic machines that are crucial for stress resistance and virulence. ClpC requires cooperation… read more here.
Keywords: clpc; meca clpc; clpp; staphylococcus aureus ... See more keywords