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   Articles with "clpp" as a keyword



Ischemic preconditioning attenuates ischemia/reperfusion‐induced acute kidney injury dependent on mitochondrial protease CLPP

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recommendations! Published in 2025 at "IUBMB Life"

DOI: 10.1002/iub.70015

Abstract: Ischemic preconditioning (IPC) is a phenomenon in which brief periods of ischemia trigger protective mechanisms that alleviate subsequent ischemia–reperfusion injury (IRI), although the precise protective mechanism remains unclear. This study investigated the mechanism by which… read more here.

Keywords: ischemia reperfusion; clpp; ischemic preconditioning; injury ... See more keywords

ClpXP affects the cell metabolism of Salmonella typhimurium partially in an RpoS-dependent manner

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recommendations! Published in 2017 at "Metabolomics"

DOI: 10.1007/s11306-017-1296-6

Abstract: IntroductionClpXP protease is an important proteolytic system in Salmonella enterica serovar typhimurium (S. typhimurium). Inactivation of ClpXP by deletion of clpP resulted in overproduction of RpoS and a growth defect phenotype. Only one report has… read more here.

Keywords: rpos; salmonella; cell metabolism; clpp ... See more keywords

Senescent Hepatocytes in Decompensated Liver Show Reduced UPRMT and Its Key Player, CLPP, Attenuates Senescence In Vitro

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recommendations! Published in 2019 at "Cellular and Molecular Gastroenterology and Hepatology"

DOI: 10.1016/j.jcmgh.2019.03.001

Abstract: Background and Aims Non-dividing hepatocytes in end-stage liver disease indicates permanent growth arrest similar to senescence. Identifying senescence in vivo is often challenging and mechanisms inhibiting senescence are poorly understood. In lower organisms mitochondrial unfolded… read more here.

Keywords: senescent hepatocytes; hepatocyte senescence; cirrhosis; senescence ... See more keywords

Mitochondrial protease ClpP supplementation ameliorates diet-induced NASH in mice.

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recommendations! Published in 2022 at "Journal of hepatology"

DOI: 10.1016/j.jhep.2022.03.034

Abstract: BACKGROUND & AIMS Mitochondrial dysfunction is considered a pathogenic linker in the development of non-alcoholic steatohepatitis (NASH). Inappropriate mitochondrial protein-quality control, possibly induced due to insufficiency of the mitochondrial matrix caseinolytic protease P (ClpP), can… read more here.

Keywords: mice; mitochondrial dysfunction; induced nash; clpp ... See more keywords

Structure-Based Design and Development of Phosphine Oxides as a Novel Chemotype for Antibiotics that Dysregulate Bacterial ClpP Proteases.

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recommendations! Published in 2024 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.4c00773

Abstract: A series of arylsulfones and heteroarylsulfones have previously been demonstrated to dysregulate the conserved bacterial ClpP protease, causing the unspecific degradation of essential cellular housekeeping proteins and ultimately resulting in cell death. A cocrystal structure… read more here.

Keywords: structure based; structure; phosphine; bacterial clpp ... See more keywords

Tamarixetin Attenuated the Virulence of Staphylococcus aureus by Directly Targeting Caseinolytic Protease P.

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recommendations! Published in 2022 at "Journal of natural products"

DOI: 10.1021/acs.jnatprod.2c00138

Abstract: Staphylococcus aureus, especially drug-resistant S. aureus infections, is a worldwide healthcare challenge. There is a growing focus on antivirulence therapy against S. aureus. Caseinolytic protease p (ClpP) is a protein hydrolase essential for pathogenicity in… read more here.

Keywords: staphylococcus aureus; tamarixetin; clpp; caseinolytic protease ... See more keywords

Proteolytic Regulation in the Biosynthesis of Natural Product Via a ClpP Protease System.

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recommendations! Published in 2024 at "ACS chemical biology"

DOI: 10.1021/acschembio.4c00304

Abstract: Protein degradation is a tightly regulated biological process that maintains bacterial proteostasis. ClpPs are a highly conserved family of serine proteases that associate with the AAA + ATPase (an ATPase associated with diverse cellular activities)… read more here.

Keywords: aaa atpase; clpp proteolytic; degradation; clpp degradation ... See more keywords

Chemical Modulation of the Human Mitochondrial ClpP: Potential Application in Cancer Therapeutics.

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recommendations! Published in 2019 at "ACS chemical biology"

DOI: 10.1021/acschembio.9b00347

Abstract: The human ClpP proteolytic complex (HsClpP) is a serine protease located in the mitochondrial matrix and participates in the maintenance of the mitochondrial proteome among other cellular functions. HsClpP typically forms a multimeric complex with… read more here.

Keywords: hsclpp; modulation human; clpp; chemical modulation ... See more keywords

Clostridium difficile ClpP Homologues are Capable of Uncoupled Activity and Exhibit Different Levels of Susceptibility to Acyldepsipeptide Modulation.

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recommendations! Published in 2019 at "ACS infectious diseases"

DOI: 10.1021/acsinfecdis.8b00199

Abstract: Caseinolytic protease P (ClpP) has emerged as a promising new target for antibacterial development. While ClpPs from single isoform expressing bacteria have been studied in detail, the function and regulation of systems with more than… read more here.

Keywords: clostridium difficile; clpp system; system difficile; clpp ... See more keywords

Dynamic Oligomerization Processes of Bacillus subtilis ClpP Protease Induced by ADEP1 Studied with High-Speed Atomic Force Microscopy

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recommendations! Published in 2025 at "ACS Omega"

DOI: 10.1021/acsomega.4c11303

Abstract: Bacterial ClpPs are a highly conserved family of serine proteases that associate with members of the AAA+ ATPase (ATPase associated with diverse cellular activities) family to degrade protein substrates. The antibiotic A54556 factor (ADEP1) induces… read more here.

Keywords: dynamic oligomerization; bacillus subtilis; subtilis clpp; clpp ... See more keywords

Molecular insights into the dynamic modulation of bacterial ClpP function and oligomerization by peptidomimetic boronate compounds

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-51787-0

Abstract: Bacterial caseinolytic protease P subunit (ClpP) is important and vital for cell survival and infectivity. Recent publications describe and discuss the complex structure–function relationship of ClpP and its processive activity mediated by 14 catalytic sites.… read more here.

Keywords: peptidomimetic boronate; function; molecular insights; clpp ... See more keywords