ClpXP affects the cell metabolism of Salmonella typhimurium partially in an RpoS-dependent manner
Sign Up to like & getrecommendations! Published in 2017 at "Metabolomics"
DOI: 10.1007/s11306-017-1296-6
Abstract: IntroductionClpXP protease is an important proteolytic system in Salmonella enterica serovar typhimurium (S. typhimurium). Inactivation of ClpXP by deletion of clpP resulted in overproduction of RpoS and a growth defect phenotype. Only one report has… read more here.
Keywords: rpos; salmonella; cell metabolism; clpp ... See more keywords
Senescent Hepatocytes in Decompensated Liver Show Reduced UPRMT and Its Key Player, CLPP, Attenuates Senescence In Vitro
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2019.03.001
Abstract: Background and Aims Non-dividing hepatocytes in end-stage liver disease indicates permanent growth arrest similar to senescence. Identifying senescence in vivo is often challenging and mechanisms inhibiting senescence are poorly understood. In lower organisms mitochondrial unfolded… read more here.
Keywords: senescent hepatocytes; hepatocyte senescence; cirrhosis; senescence ... See more keywords
Mitochondrial protease ClpP supplementation ameliorates diet-induced NASH in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2022.03.034
Abstract: BACKGROUND & AIMS Mitochondrial dysfunction is considered a pathogenic linker in the development of non-alcoholic steatohepatitis (NASH). Inappropriate mitochondrial protein-quality control, possibly induced due to insufficiency of the mitochondrial matrix caseinolytic protease P (ClpP), can… read more here.
Keywords: mice; mitochondrial dysfunction; induced nash; clpp ... See more keywords
Tamarixetin Attenuated the Virulence of Staphylococcus aureus by Directly Targeting Caseinolytic Protease P.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00138
Abstract: Staphylococcus aureus, especially drug-resistant S. aureus infections, is a worldwide healthcare challenge. There is a growing focus on antivirulence therapy against S. aureus. Caseinolytic protease p (ClpP) is a protein hydrolase essential for pathogenicity in… read more here.
Keywords: staphylococcus aureus; tamarixetin; clpp; caseinolytic protease ... See more keywords
Chemical Modulation of the Human Mitochondrial ClpP: Potential Application in Cancer Therapeutics.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00347
Abstract: The human ClpP proteolytic complex (HsClpP) is a serine protease located in the mitochondrial matrix and participates in the maintenance of the mitochondrial proteome among other cellular functions. HsClpP typically forms a multimeric complex with… read more here.
Keywords: hsclpp; modulation human; clpp; chemical modulation ... See more keywords
Clostridium difficile ClpP Homologues are Capable of Uncoupled Activity and Exhibit Different Levels of Susceptibility to Acyldepsipeptide Modulation.
Sign Up to like & getrecommendations! Published in 2019 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.8b00199
Abstract: Caseinolytic protease P (ClpP) has emerged as a promising new target for antibacterial development. While ClpPs from single isoform expressing bacteria have been studied in detail, the function and regulation of systems with more than… read more here.
Keywords: clostridium difficile; clpp system; system difficile; clpp ... See more keywords
Nepetin reduces virulence factors expression by targeting ClpP against MRSA-induced pneumonia infection
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2051313
Abstract: ABSTRACT The resistance of Staphylococcus aureus (S. aureus) to various antibiotics has increased dramatically due to the misuse of antibiotics, and thus the development of new anti-infective drugs with new targets is urgently needed to… read more here.
Keywords: nepetin clpp; infection; virulence; clpp ... See more keywords
EXTH-74. IND-ENABLING CHARACTERIZATION OF DUAL DRD2- AND ClpP-TARGETING AGENT ONC206 AS THE NEXT IMIPRIDONE FOR CLINICAL NEURO-ONCOLOGY
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.428
Abstract: ONC201 is the first bitopic antagonist of dopamine receptor D2 (DRD2) and allosteric mitochondrial protease ClpP agonist, that is well tolerated and induces durable tumor regressions in H3 K27M-mutant glioma patients. ONC206, a derivative of… read more here.
Keywords: onc206; cell lines; clpp; neuro oncology ... See more keywords
A Clinically Selected Staphylococcus aureus clpP Mutant Survives Daptomycin Treatment by Reducing Binding of the Antibiotic and Adapting a Rod-Shaped Morphology
Sign Up to like & getrecommendations! Published in 2023 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00328-23
Abstract: Daptomycin is a last-resort antibiotic used for the treatment of infections caused by Gram-positive antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). Treatment failure is commonly linked to accumulation of point mutations; however, the contribution… read more here.
Keywords: daptomycin; staphylococcus aureus; resistance; clpp ... See more keywords
Identification of ClpP Dual Isoform Disruption as an Anti-sporulation Strategy for Clostridioides difficile.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of bacteriology"
DOI: 10.1128/jb.00411-21
Abstract: The Gram-positive bacterium Clostridioides difficile is a primary cause of hospital-acquired diarrhea, threatening both immunocompromised and healthy individuals. An important aspect of defining mechanisms that drive C. difficile persistence and virulence relies on developing a… read more here.
Keywords: sporulation; anti sporulation; difficile sporulation; clostridioides difficile ... See more keywords
Abstract 3843: Potent human ClpP protease agonists with anticancer properties bind the enzyme with improved structural complementarity and alter the mitochondrial N-terminome
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3843
Abstract: The mitochondrial ClpP protease is responsible for mitochondrial protein quality control through specific degradation of proteins involved in several metabolic processes. ClpP overexpression is also required in many cancer cells to eliminate ROS-damaged proteins and… read more here.
Keywords: potent human; clpp protease; complementarity; clpp ... See more keywords