Heme-dependent recognition of 5-aminolevulinate synthase by the human mitochondrial molecular chaperone ClpX.
Sign Up to like & getrecommendations! Published in 2021 at "FEBS letters"
DOI: 10.1002/1873-3468.14214
Abstract: The caseinolytic mitochondrial matrix peptidase chaperone subunit (ClpX) plays an important role in the heme-dependent regulation of 5-aminolevulinate synthase (ALAS1), a key enzyme in heme biosynthesis. However, the mechanisms underlying the role of ClpX in… read more here.
Keywords: dependent recognition; clpx; alas1; aminolevulinate synthase ... See more keywords
Mitochondrial ClpX Inhibition Induces Ferroptosis and Blocks Pancreatic Cancer Cell Proliferation
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DOI: 10.1002/cbic.202500551
Abstract: The ATPase caseinolytic protease X (ClpX), forming the ClpXP complex with caseinolytic protease P (ClpP), is essential for mitochondrial protein homeostasis. While ClpP targeting is a recognized anticancer strategy, the role of ClpX in cancer… read more here.
Keywords: cancer; clpx inhibition; cell proliferation; clpx ... See more keywords
Progress and Prospect of Single-molecular ClpX ATPase Researching system-a mini-review.
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DOI: 10.1016/j.gene.2021.145420
Abstract: ClpXP in Escherichia coli is a proteasome degrading protein substrates. It consists of one hexamer of ATPase (ClpX) and two heptamers of peptidase (ClpP). The ClpX binds ATP and translocates the substrate protein into the… read more here.
Keywords: mini review; progress; atpase; single molecular ... See more keywords
Disruption of the ATP-dependent unfoldase ClpX reverses antifungal resistance in Cryptococcus neoformans
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DOI: 10.1038/s41467-025-61412-x
Abstract: Fungal diseases impact the lives of a millions of people across the globe, and with our current repertoire of therapeutic options dwindling, effective treatment strategies are urgently needed. Critically, the emergence of azole-resistant isolates in… read more here.
Keywords: resistance; dependent unfoldase; cryptococcus neoformans; clpx ... See more keywords
ClpX/P-Dependent Degradation of Novel Substrates in Streptococcus mutans
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DOI: 10.1128/jb.00594-21
Abstract: ClpX/P is a major intracellular proteolytic complex that is responsible for protein quality control in the cell. ClpX, an AAA+ ATPase, distinguishes the potential substrates by recognizing short motifs at the C-terminal end of proteins… read more here.
Keywords: clpx substrates; dependent degradation; streptococcus mutans; clpx ... See more keywords
Selectivity among Anti-σ Factors by Mycobacterium tuberculosis ClpX Influences Intracellular Levels of Extracytoplasmic Function σ Factors
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DOI: 10.1128/jb.00748-18
Abstract: The ability of Mycobacterium tuberculosis to quickly adapt to changing environmental stimuli occurs by maintaining protein homeostasis. Extracytoplasmic function (ECF) σ factors play a significant role in coordinating the transcription profile to changes in environmental… read more here.
Keywords: extracytoplasmic function; mycobacterium tuberculosis; anti factors; tuberculosis ... See more keywords
Tag-Dependent Substrate Selection of ClpX Underlies Secondary Differentiation of Chlamydia trachomatis
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DOI: 10.1128/mbio.01858-22
Abstract: Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections and preventable infectious blindness. This unique organism undergoes developmental transitions between infectious, nondividing forms and noninfectious, dividing forms. ABSTRACT Despite having a highly reduced… read more here.
Keywords: secondary differentiation; chlamydia trachomatis; chlamydia; clpx ... See more keywords
Unraveling proteomic chaos by independent component analysis—ClpX proficiency promotes the iron and oxygen limitation responses of Staphylococcus aureus and affects the intracellular bacterial behavior
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DOI: 10.1128/msystems.01092-25
Abstract: ABSTRACT In the opportunistic pathogen Staphylococcus aureus, protein homeostasis is largely mediated by the caseinolytic protease (Clp) system. The proteases ClpXP and ClpCP are crucial for general and targeted proteolysis, which rely on the unfoldases… read more here.
Keywords: oxygen limitation; infection; staphylococcus aureus; clpx ... See more keywords
The Essential Role of ClpXP in Caulobacter crescentus Requires Species Constrained Substrate Specificity
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DOI: 10.3389/fmolb.2017.00028
Abstract: The ClpXP protease is a highly conserved AAA+ degradation machine that is present throughout bacteria and in eukaryotic organelles. ClpXP is essential in some bacteria, such as Caulobacter crescentus, but dispensible in others, such as… read more here.
Keywords: caulobacter; clpx; clpxp; role ... See more keywords
A Staphylococcus aureus clpX Mutant Used as a Unique Screening Tool to Identify Cell Wall Synthesis Inhibitors that Reverse β-Lactam Resistance in MRSA
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DOI: 10.3389/fmolb.2021.691569
Abstract: Staphylococcus aureus is a leading cause of bacterial infections world-wide. Staphylococcal infections are preferentially treated with β-lactam antibiotics, however, methicillin-resistant S. aureus (MRSA) strains have acquired resistance to this superior class of antibiotics. We have… read more here.
Keywords: clpx; resistance; mrsa; cell wall ... See more keywords
Insight into the RssB-Mediated Recognition and Delivery of σs to the AAA+ Protease, ClpXP
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DOI: 10.3390/biom10040615
Abstract: In Escherichia coli, SigmaS (σS) is the master regulator of the general stress response. The cellular levels of σS are controlled by transcription, translation and protein stability. The turnover of σS, by the AAA+ protease… read more here.
Keywords: recognition delivery; clpx; recognition; rssb ... See more keywords