Determining the Effects of Differential Expression of GRKs and β-arrestins on CLR-RAMP Agonist Bias
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DOI: 10.3389/fphys.2022.840763
Abstract: Signalling of the calcitonin-like receptor (CLR) is multifaceted, due to its interaction with receptor activity modifying proteins (RAMPs), and three endogenous peptide agonists. Previous studies have focused on the bias of G protein signalling mediated… read more here.
Keywords: expression; determining effects; clr ramp; effects differential ... See more keywords
Sustained Activation of CLR/RAMP Receptors by Gel-Forming Agonists
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DOI: 10.3390/ijms232113408
Abstract: Background: Adrenomedullin (ADM), adrenomedullin 2 (ADM2), and CGRP family peptides are important regulators of vascular vasotone and integrity, neurotransmission, and fetoplacental development. These peptides signal through CLR/RAMP1, 2, and 3 receptors, and protect against endothelial… read more here.
Keywords: activation clr; gel forming; sustained activation; clr ramp ... See more keywords